Modification of the size of developing infarcts in the ligated dog heart by betahistine-hcl

Louis Terracio, William G. Kubicek

    Research output: Contribution to journalArticlepeer-review


    The effectiveness of ß-histine-HCl in modifying the size of developing myocardial infarcts was tested in the surgically ligated dog. Branches of the left coronary artery were ligated and a 6-hour continuous intravenous infusion of 0.24 mg/kg/min of ß-histine was administered from 0 to 120 min after ligation. The effect of this treatment was evaluated histologically in studies on acute ischemia by the use of the hematoxylin-basic fuchsin-picric acid stain for early myocardial ischemia. The treatment was also evaluated grossly in a study on chronic ischemia where the dogs were permitted to survive for 30 days before sacrifice. In these experiments, the size of infarcts found in the ß-histine-treated animals was compared with those found in the saline controls. Both studies showed that the control ligations produced a large uniform area of ischemia or infarction that was greatly reduced or prevented by immediate treatment with ß-histine. Also, ß-histine was capable of significantly reducing the size of developing infarcts for up to 120 min after ligation.

    Original languageEnglish (US)
    Pages (from-to)372-379
    Number of pages8
    JournalCells Tissues Organs
    Issue number4
    StatePublished - 1978


    • Collateral circulation
    • Heart
    • Myocardial infarction
    • Vasodilator
    • ß-histine-HC1

    ASJC Scopus subject areas

    • Anatomy
    • Histology


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