Modulation of bacterial aggregation by PMN and platelet extracts

D. Malamud, R. Goldman, N. S. Taichman

Research output: Contribution to journalArticlepeer-review

Abstract

Human parotid saliva contains agglutinins which bind to the surface of streptococci and induce the formation of bacterial aggregates. Bacterial aggregation can be blocked by proteins released from viable PMNs and platelets or by sonic extracts prepared from these cells. PMN and platelet inhibitors display characteristic differences in molecular weight, protease, and temperature sensitivity. The mechanism of action of the inhibitors appears to involve a direct interaction with the salivary agglutinins rather than with the bacteria. It is thus possible that PMN and platelet-derived products might modulate saliva-mediated bacterial aggregation and thereby influence the course of infections in the oral cavity.

Original languageEnglish (US)
Pages (from-to)133-144
Number of pages12
JournalInflammation
Volume7
Issue number2
DOIs
StatePublished - Jun 1983

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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