Molecular design of inorganic-binding polypeptides

John Spencer Evans, Ram Samudrala, Tiffany R. Walsh, Ersin Emre Oren, Candan Tamerler

Research output: Contribution to journalArticle

Abstract

Controlled binding and assembly of peptides onto inorganic substrates is at the core of bionanotechnology and biological-materials engineering. Peptides offer several unique advantages for developing future inorganic materials and systems. First, engineered polypeptides can molecularly recognize inorganic surfaces that are distinguishable by shape, crystallography, mineralogy, and chemistry. Second, polypeptides are capable of self-assembly on specific material surfaces leading to addressable molecular architectures. Finally, genetically engineered peptides offer multiple strategies for their functional modification. In this article, we summarize the details and mechanisms involved in combinatorial-polypeptide sequence selection and inorganic-material recognition and affinity, and outline experimental and theoretical approaches and concepts that will help advance this emerging field.

Original languageEnglish (US)
Pages (from-to)514-518
Number of pages5
JournalMRS Bulletin
Volume33
Issue number5
DOIs
StatePublished - May 2008

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

Fingerprint Dive into the research topics of 'Molecular design of inorganic-binding polypeptides'. Together they form a unique fingerprint.

Cite this