Molecular mechanisms of threat learning in the lateral nucleus of the amygdala

Robert M. Sears, Hillary C. Schiff, Joseph E. Ledoux

Research output: Chapter in Book/Report/Conference proceedingChapter


Pavlovian threat conditioning is a behavioral paradigm that has been successfully utilized to define the mechanisms underlying threat (fear) memory formation. The amygdala is a temporal lobe structure required for the acquisition, consolidation, and expression of threat (fear) memories. In particular, the lateral nucleus of the amygdala (LA) is the major input structure of the amygdala and is required for all aspects of threat learning and memory. The LA expresses many neurotransmitter and neuromodulator receptors. This chapter covers the molecular mechanisms that occur downstream of these receptors and how they influence LA-dependent Pavlovian threat learning.

Original languageEnglish (US)
Title of host publicationMolecular Basis of Memory
PublisherElsevier B.V.
Number of pages42
StatePublished - 2014

Publication series

NameProgress in Molecular Biology and Translational Science
ISSN (Print)1877-1173


  • Acquisition
  • Amygdala
  • Consolidation
  • Fear conditioning
  • Molecular mechanisms
  • Plasticity
  • Signaling pathways
  • Threat conditioning

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology


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