@inproceedings{4534ca09e4434664a5cb92e3c3ce6f30,
title = "Monitoring total hemoglobin concentration changes across neoadjuvant chemotherapy in PgR-positive and PgR-negative breast cancer with diffuse optical tomography",
abstract = "The aim of this study was to investigate the optical chemotherapy changes induced by neoadjuvant chemotherapy (NAC) in PgR-positive and PgR-negative breast cancer subtypes using a diffuse optical tomographic breast imaging system (DOTBIS). ctTHb reduction in the tumor volume was greater for patients with PgR-negative, a statistically significant difference of 48.91μM, p =.022, which suggest that PgR-negative tumors are generally less resistant to NAC. These observations indicate that PgR negativity may be combined to optically derived biomarkers for predicting pCR during neoadjuvant chemotherapy.",
keywords = "Breast cancer, CtTHb reduction, Diffuse optical tomography, Neoadjuvant chemotherapy, Pgr-negative",
author = "Altoe, {Mirella L.} and Alessandro Marone and Kim, {Hyun K.} and Mariella Tejada and Hanina Hibshoosh and Katherine Crew and Kevin Kalinsky and Hershman, {Dawn L.} and Hielscher, {Andreas H.}",
note = "Funding Information: This wokwras suptped inopart bragyantr from Coumbila|Biomedx - Biomedical TechoonylAgcc elerator. Furthermoe, r Mirella L. Alto{\'e} was supptedoin parrt by a fellowship from CNPq/LASPAU – Brazil [270/920141-5] and3Alessandro Marone was suopted rinpart by a Persoalizned Medicine Fellowship of the Irving Intitutse for Clinical andTra nslatioal n Research at Columbia University in the City of New York. Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.; Optical Tomography and Spectroscopy of Tissue XIII 2019 ; Conference date: 04-02-2019 Through 06-02-2019",
year = "2019",
doi = "10.1117/12.2510172",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Sergio Fantini and Paola Taroni",
booktitle = "Optical Tomography and Spectroscopy of Tissue XIII",
}