Monitoring total hemoglobin concentration changes across neoadjuvant chemotherapy in PgR-positive and PgR-negative breast cancer with diffuse optical tomography

Mirella L. Altoe, Alessandro Marone, Hyun K. Kim, Mariella Tejada, Hanina Hibshoosh, Katherine Crew, Kevin Kalinsky, Dawn L. Hershman, Andreas H. Hielscher

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    The aim of this study was to investigate the optical chemotherapy changes induced by neoadjuvant chemotherapy (NAC) in PgR-positive and PgR-negative breast cancer subtypes using a diffuse optical tomographic breast imaging system (DOTBIS). ctTHb reduction in the tumor volume was greater for patients with PgR-negative, a statistically significant difference of 48.91μM, p =.022, which suggest that PgR-negative tumors are generally less resistant to NAC. These observations indicate that PgR negativity may be combined to optically derived biomarkers for predicting pCR during neoadjuvant chemotherapy.

    Original languageEnglish (US)
    Title of host publicationOptical Tomography and Spectroscopy of Tissue XIII
    EditorsSergio Fantini, Paola Taroni
    PublisherSPIE
    ISBN (Electronic)9781510623903
    DOIs
    StatePublished - 2019
    EventOptical Tomography and Spectroscopy of Tissue XIII 2019 - San Francisco, United States
    Duration: Feb 4 2019Feb 6 2019

    Publication series

    NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
    Volume10874
    ISSN (Print)1605-7422

    Conference

    ConferenceOptical Tomography and Spectroscopy of Tissue XIII 2019
    CountryUnited States
    CitySan Francisco
    Period2/4/192/6/19

    Keywords

    • Breast cancer
    • CtTHb reduction
    • Diffuse optical tomography
    • Neoadjuvant chemotherapy
    • Pgr-negative

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Atomic and Molecular Physics, and Optics
    • Radiology Nuclear Medicine and imaging

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