Monitoring tumor growth and treatment in small animals with magnetic resonance and optical tomographic imaging

J. Masciotti, F. Provenzano, J. Papa, A. Klose, J. Hur, X. Gu, D. Yamashiro, J. Kandel, A. H. Hielscher

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Small animal models are employed to simulate disease in humans and to study its progression, what factors are important to the disease process, and to study the disease treatment. Biomedical imaging modalities such as magnetic resonance imaging (MRI) and Optical Tomography make it possible to non-invasively monitor the progression of diseases in living small animals and study the efficacy of drugs and treatment protocols. MRI is an established imaging modality capable of obtaining high resolution anatomical images and along with contrast agents allow the studying of blood volume. Optical tomography, on the other hand, is an emerging imaging modality, which, while much lower in spatial resolution, can separate the effects of oxyhemoglobin, deoxyhemoglobin, and blood volume with high temporal resolution. In this study we apply these modalities to imaging the growth of kidney tumors and then there treatment by an anti-VEGF agent. We illustrate how these imaging modalities have their individual uses, but can still supplement each other and cross validation can be performed.

    Original languageEnglish (US)
    Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
    DOIs
    StatePublished - 2006
    EventMultimodal Biomedical Imaging - San Jose, CA, United States
    Duration: Jan 21 2006Jan 24 2006

    Publication series

    NameProceedings of SPIE - The International Society for Optical Engineering
    Volume6081
    ISSN (Print)0277-786X

    Conference

    ConferenceMultimodal Biomedical Imaging
    Country/TerritoryUnited States
    CitySan Jose, CA
    Period1/21/061/24/06

    Keywords

    • MRI
    • Multimodality Imaging
    • Optical Tomography
    • Small animal imaging
    • VEGF

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Condensed Matter Physics
    • Computer Science Applications
    • Applied Mathematics
    • Electrical and Electronic Engineering

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