Monitoring tumor growth and treatment in small animals with magnetic resonance and optical tomographic imaging

J. Masciotti; F. Provenzano; J. Papa; A. Klose; J. Hur; X. Gu; D. Yamashiro; J. Kandel; A. H. Hielscher

doi:10.1117/12.647138

Monitoring tumor growth and treatment in small animals with magnetic resonance and optical tomographic imaging

J. Masciotti, F. Provenzano, J. Papa, A. Klose, J. Hur, X. Gu, D. Yamashiro, J. Kandel, A. H. Hielscher

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Small animal models are employed to simulate disease in humans and to study its progression, what factors are important to the disease process, and to study the disease treatment. Biomedical imaging modalities such as magnetic resonance imaging (MRI) and Optical Tomography make it possible to non-invasively monitor the progression of diseases in living small animals and study the efficacy of drugs and treatment protocols. MRI is an established imaging modality capable of obtaining high resolution anatomical images and along with contrast agents allow the studying of blood volume. Optical tomography, on the other hand, is an emerging imaging modality, which, while much lower in spatial resolution, can separate the effects of oxyhemoglobin, deoxyhemoglobin, and blood volume with high temporal resolution. In this study we apply these modalities to imaging the growth of kidney tumors and then there treatment by an anti-VEGF agent. We illustrate how these imaging modalities have their individual uses, but can still supplement each other and cross validation can be performed.

Original language	English (US)
Title of host publication	Proceedings of SPIE - The International Society for Optical Engineering
DOIs	https://doi.org/10.1117/12.647138
State	Published - 2006
Event	Multimodal Biomedical Imaging - San Jose, CA, United States Duration: Jan 21 2006 → Jan 24 2006

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	6081
ISSN (Print)	0277-786X

Conference

Conference	Multimodal Biomedical Imaging
Country/Territory	United States
City	San Jose, CA
Period	1/21/06 → 1/24/06

Keywords

MRI
Multimodality Imaging
Optical Tomography
Small animal imaging
VEGF

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

Access to Document

10.1117/12.647138

Cite this

Masciotti, J., Provenzano, F., Papa, J., Klose, A., Hur, J., Gu, X., Yamashiro, D., Kandel, J., & Hielscher, A. H. (2006). Monitoring tumor growth and treatment in small animals with magnetic resonance and optical tomographic imaging. In Proceedings of SPIE - The International Society for Optical Engineering Article 608105 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 6081). https://doi.org/10.1117/12.647138

Monitoring tumor growth and treatment in small animals with magnetic resonance and optical tomographic imaging. / Masciotti, J.; Provenzano, F.; Papa, J. et al.
Proceedings of SPIE - The International Society for Optical Engineering. 2006. 608105 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 6081).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Masciotti, J, Provenzano, F, Papa, J, Klose, A, Hur, J, Gu, X, Yamashiro, D, Kandel, J & Hielscher, AH 2006, Monitoring tumor growth and treatment in small animals with magnetic resonance and optical tomographic imaging. in Proceedings of SPIE - The International Society for Optical Engineering., 608105, Proceedings of SPIE - The International Society for Optical Engineering, vol. 6081, Multimodal Biomedical Imaging, San Jose, CA, United States, 1/21/06. https://doi.org/10.1117/12.647138

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AU - Gu, X.

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AB - Small animal models are employed to simulate disease in humans and to study its progression, what factors are important to the disease process, and to study the disease treatment. Biomedical imaging modalities such as magnetic resonance imaging (MRI) and Optical Tomography make it possible to non-invasively monitor the progression of diseases in living small animals and study the efficacy of drugs and treatment protocols. MRI is an established imaging modality capable of obtaining high resolution anatomical images and along with contrast agents allow the studying of blood volume. Optical tomography, on the other hand, is an emerging imaging modality, which, while much lower in spatial resolution, can separate the effects of oxyhemoglobin, deoxyhemoglobin, and blood volume with high temporal resolution. In this study we apply these modalities to imaging the growth of kidney tumors and then there treatment by an anti-VEGF agent. We illustrate how these imaging modalities have their individual uses, but can still supplement each other and cross validation can be performed.

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Monitoring tumor growth and treatment in small animals with magnetic resonance and optical tomographic imaging

Abstract

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Conference

Keywords

ASJC Scopus subject areas

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