Monte Carlo simulations incorporating Mie calculations of light transport in tissue phantoms: Examination of photon sampling volumes for endoscopically compatible fiber optic probes

Judith R. Mourant, Andreas H. Hielscher, Irving J. Bigio

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Details of the interaction of photons with tissue phantoms are elucidated using Monte Carlo simulations. In particular, photon sampling volumes and photon pathlengths are determined for a variety of scattering and absorption parameters. The Monte Carlo simulations are specifically designed to model light delivery and collection geometries relevant to clinical applications of optical biopsy techniques. The Monte Carlo simulations assume that light is delivered and collected by two, nearly-adjacent optical fibers and take into account the numerical aperture of the fibers as well as reflectance and refraction at interfaces between different media. To determine the validity of the Monte Carlo simulations for modeling the interactions between the photons and the tissue phantom in these geometries, the simulations were compared to measurements of aqueous suspensions of polystyrene microspheres in the wavelength range 450-750 nm.

Original languageEnglish (US)
Title of host publicationAdvances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases III
Subtitle of host publicationProceedings of SPIE - The International Society for Optical Engineering
Pages124-130
Number of pages7
Volume2679
DOIs
StatePublished - 1996
EventAdvances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases III: Optical Biopsy - San Jose, CA, United States
Duration: Jan 29 1996Jan 29 1996

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
PublisherSPIE
ISSN (Print)0277-786X

Conference

ConferenceAdvances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases III: Optical Biopsy
Country/TerritoryUnited States
CitySan Jose, CA
Period1/29/961/29/96

Keywords

  • Elastic-scatter
  • Mie
  • Monte Carlo
  • Photon pathlength
  • Photon sampling volume

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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