Monte Carlo simulations incorporating Mie calculations of light transport in tissue phantoms: Examination of photon sampling volumes for endoscopically compatible fiber optic probes

Judith R. Mourant, Andreas H. Hielscher, Irving J. Bigio

    Research output: Contribution to journalConference articlepeer-review

    Abstract

    Details of the interaction of photons with tissue phantoms are elucidated using Monte Carlo simulations. In particular, photon sampling volumes and photon pathlengths are determined for a variety of scattering and absorption parameters. The Monte Carlo simulations are specifically designed to model light delivery and collection geometries relevant to clinical applications of optical biopsy techniques. The Monte Carlo simulations assume that light is delivered and collected by two, nearly-adjacent optical fibers and take into account the numerical aperture of the fibers as well as reflectance and refraction at interfaces between different media. To determine the validity of the Monte Carlo simulations for modeling the interactions between the photons and the tissue phantom in these geometries, the simulations were compared to measurements of aqueous suspensions of polystyrene microspheres in the wavelength range 450-750 nm.

    Original languageEnglish (US)
    Pages (from-to)124-130
    Number of pages7
    JournalProceedings of SPIE - The International Society for Optical Engineering
    Volume2679
    DOIs
    StatePublished - 1996
    EventAdvances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases III: Optical Biopsy - San Jose, CA, United States
    Duration: Jan 29 1996Jan 29 1996

    Keywords

    • Elastic-scatter
    • Mie
    • Monte Carlo
    • Photon pathlength
    • Photon sampling volume

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Condensed Matter Physics
    • Computer Science Applications
    • Applied Mathematics
    • Electrical and Electronic Engineering

    Fingerprint Dive into the research topics of 'Monte Carlo simulations incorporating Mie calculations of light transport in tissue phantoms: Examination of photon sampling volumes for endoscopically compatible fiber optic probes'. Together they form a unique fingerprint.

    Cite this