TY - JOUR
T1 - Morphogen to mitogen
T2 - The multiple roles of hedgehog signalling in vertebrate neural development
AU - Fuccillo, Marc
AU - Joyner, Alexandra L.
AU - Fishell, Gord
N1 - Funding Information:
We would like to thank Sandra Blaess and Alex Schier for their critical reading of this review and their many helpful comments. We would also like to thank the Joyner and Fishell laboratories. A.J. and G.F. are supported by grants from the National Institutes of Health, USA.
PY - 2006/10
Y1 - 2006/10
N2 - Sonic hedgehog has received an enormous amount of attention since its role as a morphogen that directs ventral patterning in the spinal cord was discovered a decade ago. Since that time, a bewildering array of information has been generated concerning both the components of the hedgehog signalling pathway and the remarkable number of contexts in which it functions. Nowhere is this more evident than in the nervous system, where hedgehog signalling has been implicated in events as disparate as axonal guidance and stem cell maintenance. Here we review our present knowledge of the hedgehog signalling pathway and speculate about areas in which further insights into this versatile pathway might be forthcoming.
AB - Sonic hedgehog has received an enormous amount of attention since its role as a morphogen that directs ventral patterning in the spinal cord was discovered a decade ago. Since that time, a bewildering array of information has been generated concerning both the components of the hedgehog signalling pathway and the remarkable number of contexts in which it functions. Nowhere is this more evident than in the nervous system, where hedgehog signalling has been implicated in events as disparate as axonal guidance and stem cell maintenance. Here we review our present knowledge of the hedgehog signalling pathway and speculate about areas in which further insights into this versatile pathway might be forthcoming.
UR - http://www.scopus.com/inward/record.url?scp=33748951151&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748951151&partnerID=8YFLogxK
U2 - 10.1038/nrn1990
DO - 10.1038/nrn1990
M3 - Review article
C2 - 16988653
AN - SCOPUS:33748951151
SN - 1471-003X
VL - 7
SP - 772
EP - 783
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 10
ER -