Motion of molecular motor ratcheted by internal fluctuations and protein friction

A. Mogilner; M. Mangel; R. J. Baskin

doi:10.1016/S0375-9601(97)00821-9

Motion of molecular motor ratcheted by internal fluctuations and protein friction

A. Mogilner, M. Mangel, R. J. Baskin

Research output: Contribution to journal › Article › peer-review

Abstract

We investigate theoretically a novel mechanism of transducing chemical energy into a directed force. A hypothetical motor protein is considered such that conformational changes induced by nucleotide binding and/or hydrolysis lead to asymmetric internal velocity fluctuations. We demonstrate that these fluctuations result in unidirectional motion if rectified by protein friction. The motor protein force-velocity relationship and other characteristics are computed based on analogy with known molecular motors.

Original language	English (US)
Pages (from-to)	297-306
Number of pages	10
Journal	Physics Letters, Section A: General, Atomic and Solid State Physics
Volume	237
Issue number	4-5
DOIs	https://doi.org/10.1016/S0375-9601(97)00821-9
State	Published - Jan 12 1998

Keywords

Brownian ratchet
Molecular motors
Protein friction

ASJC Scopus subject areas

General Physics and Astronomy

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10.1016/S0375-9601(97)00821-9

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abstract = "We investigate theoretically a novel mechanism of transducing chemical energy into a directed force. A hypothetical motor protein is considered such that conformational changes induced by nucleotide binding and/or hydrolysis lead to asymmetric internal velocity fluctuations. We demonstrate that these fluctuations result in unidirectional motion if rectified by protein friction. The motor protein force-velocity relationship and other characteristics are computed based on analogy with known molecular motors.",

keywords = "Brownian ratchet, Molecular motors, Protein friction",

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T1 - Motion of molecular motor ratcheted by internal fluctuations and protein friction

AU - Mogilner, A.

AU - Mangel, M.

AU - Baskin, R. J.

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Y1 - 1998/1/12

N2 - We investigate theoretically a novel mechanism of transducing chemical energy into a directed force. A hypothetical motor protein is considered such that conformational changes induced by nucleotide binding and/or hydrolysis lead to asymmetric internal velocity fluctuations. We demonstrate that these fluctuations result in unidirectional motion if rectified by protein friction. The motor protein force-velocity relationship and other characteristics are computed based on analogy with known molecular motors.

AB - We investigate theoretically a novel mechanism of transducing chemical energy into a directed force. A hypothetical motor protein is considered such that conformational changes induced by nucleotide binding and/or hydrolysis lead to asymmetric internal velocity fluctuations. We demonstrate that these fluctuations result in unidirectional motion if rectified by protein friction. The motor protein force-velocity relationship and other characteristics are computed based on analogy with known molecular motors.

KW - Brownian ratchet

KW - Molecular motors

KW - Protein friction

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JO - Physics Letters, Section A: General, Atomic and Solid State Physics

JF - Physics Letters, Section A: General, Atomic and Solid State Physics

IS - 4-5

ER -

Motion of molecular motor ratcheted by internal fluctuations and protein friction

Abstract

Keywords

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