TY - JOUR
T1 - Multi-level regulation of cellular glycosylation
T2 - from genes to transcript to enzyme to structure
AU - Neelamegham, Sriram
AU - Mahal, Lara K.
N1 - Funding Information:
SN is supported by NIH/NHLBI grants HL103411 and the Program for Excellence in Glycosciences award HL107146. LKM is supported by the NIH/NIAID grant U01AI111598 .
Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Glycosylation is a ubiquitous mammalian post-translational modification that both decorates a majority of expressed proteins and regulates their function. Cellular glycan biosynthesis is facilitated by a few hundred enzymes that are collectively termed ‘glycoenzymes’. The expression and activity of these enzymes is controlled at the transcription, translation and post-translation levels. New wet-lab advances are providing analytical methods to collect large-scale data at these multiple levels, relational databases are starting to collate these results, and computer models are beginning to integrate this information across scales in order to gain new knowledge. These activities are likely to enable the qualitative and quantitative mapping of pathways regulating glycan production and function in proteins, cells and tissue.
AB - Glycosylation is a ubiquitous mammalian post-translational modification that both decorates a majority of expressed proteins and regulates their function. Cellular glycan biosynthesis is facilitated by a few hundred enzymes that are collectively termed ‘glycoenzymes’. The expression and activity of these enzymes is controlled at the transcription, translation and post-translation levels. New wet-lab advances are providing analytical methods to collect large-scale data at these multiple levels, relational databases are starting to collate these results, and computer models are beginning to integrate this information across scales in order to gain new knowledge. These activities are likely to enable the qualitative and quantitative mapping of pathways regulating glycan production and function in proteins, cells and tissue.
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U2 - 10.1016/j.sbi.2016.09.013
DO - 10.1016/j.sbi.2016.09.013
M3 - Review article
C2 - 27744149
AN - SCOPUS:84992035571
SN - 0959-440X
VL - 40
SP - 145
EP - 152
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
ER -