Multifunctional magnetic nanoparticles elicit anti-tumor immunity in a mouse melanoma model

Nuria Lafuente-Gómez, Irene de Lázaro, Mónica Dhanjani, David García-Soriano, Miguel C. Sobral, Gorka Salas, David J. Mooney, Álvaro Somoza

Research output: Contribution to journalArticlepeer-review


Immunotherapy has emerged as a promising strategy to eradicate cancer cells. Particularly, the development of cancer vaccines to induce a potent and sustained antigen-specific T cell response has become a center of attention. Herein, we describe a novel immunotherapy based on magnetic nanoparticles (MNP) covalently modified with the OVA254-267 antigen and a CpG oligonucleotide via disulfide bonds. The MNP-CpG-COVA significantly enhances dendritic cell activation and CD8+ T cell antitumoral response against B16-OVA melanoma cells in vitro. Notably, the immune response induced by the covalently modified MNP is more potent and sustained over time than that triggered by the free components, highlighting the advantage of nanoformulations in immunotherapies. What is more, the nanoparticles are stable in the blood after in vivo administration and induce potent levels of systemic tumor-specific effector CD8 + T cells. Overall, our findings highlight the potential of covalently functionalized MNP to induce robust immune responses against mouse melanoma.

Original languageEnglish (US)
Article number100817
JournalMaterials Today Bio
StatePublished - Dec 2023


  • Cancer immunotherapy
  • Cancer vaccine
  • Magnetic nanoparticles
  • Nanomedicine

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering
  • Molecular Biology
  • Cell Biology


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