Abstract
A straightforward methodology for the synthesis of multifunctionalized dendrimers that is based on an orthogonal functionalization strategy has been developed. Polyamide-based dendrimers that possess both a single aldehyde and a single azide moiety on their periphery have been synthesized by using a convergent synthetic strategy. These dendrimers can be functionalized quantitatively with small organic and biological molecules that contain hydrazide and/or alkyne groups in which each functional moiety is completely specific for its complementary motif. This orthogonal functionalization strategy has the potential to be used to synthesize multifunctional dendrimers for a variety of applications, which range from targeted biological delivery vehicles to optical materials.
Original language | English (US) |
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Pages (from-to) | 8801-8810 |
Number of pages | 10 |
Journal | Chemistry - A European Journal |
Volume | 13 |
Issue number | 31 |
DOIs | |
State | Published - 2007 |
Keywords
- Chemical biology
- Click chemistry
- Dendrimers
- Functionalization
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry