Multiparametric MRI for prostate cancer diagnosis: current status and future directions

Armando Stabile, Francesco Giganti, Andrew B. Rosenkrantz, Samir S. Taneja, Geert Villeirs, Inderbir S. Gill, Clare Allen, Mark Emberton, Caroline M. Moore, Veeru Kasivisvanathan

Research output: Contribution to journalReview articlepeer-review


The current diagnostic pathway for prostate cancer has resulted in overdiagnosis and consequent overtreatment as well as underdiagnosis and missed diagnoses in many men. Multiparametric MRI (mpMRI) of the prostate has been identified as a test that could mitigate these diagnostic errors. The performance of mpMRI can vary depending on the population being studied, the execution of the MRI itself, the experience of the radiologist, whether additional biomarkers are considered and whether mpMRI-targeted biopsy is carried out alone or in addition to systematic biopsy. A number of challenges to implementation remain, such as ensuring high-quality execution and reporting of mpMRI and ensuring that this diagnostic pathway is cost-effective. Nevertheless, emerging clinical trial data support the adoption of this technology as part of the standard of care for the diagnosis of prostate cancer.

Original languageEnglish (US)
Pages (from-to)41-61
Number of pages21
JournalNature Reviews Urology
Issue number1
StatePublished - Jan 1 2020

ASJC Scopus subject areas

  • Urology


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