Multiple FLC haplotypes defined by independent cisregulatory variation underpin life history diversity in Arabidopsis thaliana

Peijin Li; Daniele Filiault; Mathew S. Box; Envel Kerdaffrec; Cock van Oosterhout; Amity M. Wilczek; Johanna Schmitt; Mark McMullan; Joy Bergelson; Magnus Nordborg; Caroline Dean

doi:10.1101/gad.245993.114

Multiple FLC haplotypes defined by independent cisregulatory variation underpin life history diversity in Arabidopsis thaliana

Peijin Li, Daniele Filiault, Mathew S. Box, Envel Kerdaffrec, Cock van Oosterhout, Amity M. Wilczek, Johanna Schmitt, Mark McMullan, Joy Bergelson, Magnus Nordborg, Caroline Dean

Biology and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

Relating molecular variation to phenotypic diversity is a central goal in evolutionary biology. In Arabidopsis thaliana, FLOWERING LOCUS C (FLC) is a major determinant of variation in vernalization-the acceleration of flowering by prolonged cold. Here, through analysis of 1307 A. thaliana accessions, we identify five predominant FLC haplotypes defined by noncoding sequence variation. Genetic and transgenic experiments show that they are functionally distinct, varying in FLC expression level and rate of epigenetic silencing. Allelic heterogeneity at this single locus accounts for a large proportion of natural variation in vernalization that contributes to adaptation of A. thaliana.

Original language	English (US)
Pages (from-to)	1635-1640
Number of pages	6
Journal	Genes and Development
Volume	28
Issue number	15
DOIs	https://doi.org/10.1101/gad.245993.114
State	Published - 2014

Keywords

Adaptation
Allelic heterogeneity
FLOWERING LOCUS C
Noncoding polymorphism
Vernalization

ASJC Scopus subject areas

Genetics
Developmental Biology

Access to Document

10.1101/gad.245993.114

Cite this

@article{cac698678d634b108bbc1187e175fee6,

title = "Multiple FLC haplotypes defined by independent cisregulatory variation underpin life history diversity in Arabidopsis thaliana",

abstract = "Relating molecular variation to phenotypic diversity is a central goal in evolutionary biology. In Arabidopsis thaliana, FLOWERING LOCUS C (FLC) is a major determinant of variation in vernalization-the acceleration of flowering by prolonged cold. Here, through analysis of 1307 A. thaliana accessions, we identify five predominant FLC haplotypes defined by noncoding sequence variation. Genetic and transgenic experiments show that they are functionally distinct, varying in FLC expression level and rate of epigenetic silencing. Allelic heterogeneity at this single locus accounts for a large proportion of natural variation in vernalization that contributes to adaptation of A. thaliana.",

keywords = "Adaptation, Allelic heterogeneity, FLOWERING LOCUS C, Noncoding polymorphism, Vernalization",

author = "Peijin Li and Daniele Filiault and Box, {Mathew S.} and Envel Kerdaffrec and {van Oosterhout}, Cock and Wilczek, {Amity M.} and Johanna Schmitt and Mark McMullan and Joy Bergelson and Magnus Nordborg and Caroline Dean",

year = "2014",

doi = "10.1101/gad.245993.114",

language = "English (US)",

volume = "28",

pages = "1635--1640",

journal = "Genes and Development",

issn = "0890-9369",

publisher = "Cold Spring Harbor Laboratory Press",

number = "15",

}

TY - JOUR

T1 - Multiple FLC haplotypes defined by independent cisregulatory variation underpin life history diversity in Arabidopsis thaliana

AU - Li, Peijin

AU - Filiault, Daniele

AU - Box, Mathew S.

AU - Kerdaffrec, Envel

AU - van Oosterhout, Cock

AU - Wilczek, Amity M.

AU - Schmitt, Johanna

AU - McMullan, Mark

AU - Bergelson, Joy

AU - Nordborg, Magnus

AU - Dean, Caroline

PY - 2014

Y1 - 2014

N2 - Relating molecular variation to phenotypic diversity is a central goal in evolutionary biology. In Arabidopsis thaliana, FLOWERING LOCUS C (FLC) is a major determinant of variation in vernalization-the acceleration of flowering by prolonged cold. Here, through analysis of 1307 A. thaliana accessions, we identify five predominant FLC haplotypes defined by noncoding sequence variation. Genetic and transgenic experiments show that they are functionally distinct, varying in FLC expression level and rate of epigenetic silencing. Allelic heterogeneity at this single locus accounts for a large proportion of natural variation in vernalization that contributes to adaptation of A. thaliana.

AB - Relating molecular variation to phenotypic diversity is a central goal in evolutionary biology. In Arabidopsis thaliana, FLOWERING LOCUS C (FLC) is a major determinant of variation in vernalization-the acceleration of flowering by prolonged cold. Here, through analysis of 1307 A. thaliana accessions, we identify five predominant FLC haplotypes defined by noncoding sequence variation. Genetic and transgenic experiments show that they are functionally distinct, varying in FLC expression level and rate of epigenetic silencing. Allelic heterogeneity at this single locus accounts for a large proportion of natural variation in vernalization that contributes to adaptation of A. thaliana.

KW - Adaptation

KW - Allelic heterogeneity

KW - FLOWERING LOCUS C

KW - Noncoding polymorphism

KW - Vernalization

UR - http://www.scopus.com/inward/record.url?scp=84905250926&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905250926&partnerID=8YFLogxK

U2 - 10.1101/gad.245993.114

DO - 10.1101/gad.245993.114

M3 - Article

C2 - 25035417

AN - SCOPUS:84905250926

SN - 0890-9369

VL - 28

SP - 1635

EP - 1640

JO - Genes and Development

JF - Genes and Development

IS - 15

ER -

Multiple FLC haplotypes defined by independent cisregulatory variation underpin life history diversity in Arabidopsis thaliana

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this