TY - JOUR
T1 - Multiregion transcriptomic profiling of the primate brain reveals signatures of aging and the social environment
AU - Cayo Biobank Research Unit
AU - Chiou, Kenneth L.
AU - DeCasien, Alex R.
AU - Rees, Katherina P.
AU - Testard, Camille
AU - Spurrell, Cailyn H.
AU - Gogate, Aishwarya A.
AU - Pliner, Hannah A.
AU - Tremblay, Sébastien
AU - Mercer, Arianne
AU - Whalen, Connor J.
AU - Negrón-Del Valle, Josué E.
AU - Janiak, Mareike C.
AU - Bauman Surratt, Samuel E.
AU - González, Olga
AU - Compo, Nicole R.
AU - Stock, Michala K.
AU - Ruiz-Lambides, Angelina V.
AU - Martínez, Melween I.
AU - Wilson, Melissa A.
AU - Melin, Amanda D.
AU - Antón, Susan C.
AU - Walker, Christopher S.
AU - Sallet, Jérôme
AU - Newbern, Jason M.
AU - Starita, Lea M.
AU - Shendure, Jay
AU - Higham, James P.
AU - Brent, Lauren J.N.
AU - Montague, Michael J.
AU - Platt, Michael L.
AU - Snyder-Mackler, Noah
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2022/12
Y1 - 2022/12
N2 - Aging is accompanied by a host of social and biological changes that correlate with behavior, cognitive health and susceptibility to neurodegenerative disease. To understand trajectories of brain aging in a primate, we generated a multiregion bulk (N = 527 samples) and single-nucleus (N = 24 samples) brain transcriptional dataset encompassing 15 brain regions and both sexes in a unique population of free-ranging, behaviorally phenotyped rhesus macaques. We demonstrate that age-related changes in the level and variance of gene expression occur in genes associated with neural functions and neurological diseases, including Alzheimer’s disease. Further, we show that higher social status in females is associated with younger relative transcriptional ages, providing a link between the social environment and aging in the brain. Our findings lend insight into biological mechanisms underlying brain aging in a nonhuman primate model of human behavior, cognition and health.
AB - Aging is accompanied by a host of social and biological changes that correlate with behavior, cognitive health and susceptibility to neurodegenerative disease. To understand trajectories of brain aging in a primate, we generated a multiregion bulk (N = 527 samples) and single-nucleus (N = 24 samples) brain transcriptional dataset encompassing 15 brain regions and both sexes in a unique population of free-ranging, behaviorally phenotyped rhesus macaques. We demonstrate that age-related changes in the level and variance of gene expression occur in genes associated with neural functions and neurological diseases, including Alzheimer’s disease. Further, we show that higher social status in females is associated with younger relative transcriptional ages, providing a link between the social environment and aging in the brain. Our findings lend insight into biological mechanisms underlying brain aging in a nonhuman primate model of human behavior, cognition and health.
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U2 - 10.1038/s41593-022-01197-0
DO - 10.1038/s41593-022-01197-0
M3 - Article
C2 - 36424430
AN - SCOPUS:85142610972
SN - 1097-6256
VL - 25
SP - 1714
EP - 1723
JO - Nature Neuroscience
JF - Nature Neuroscience
IS - 12
ER -