Multiregional communication and the channel modulation hypothesis

Bijan Pesaran, Maureen Hagan, Shaoyu Qiao, Ryan Shewcraft

Research output: Contribution to journalReview articlepeer-review


Multiregional communication is important to understanding the brain mechanisms supporting complex behaviors. Work in animals and human subjects shows that multiregional communication plays significant roles in cognitive function and is associated with neurological and neuropsychiatric disorders of brain function. Recent experimental advances enable empirical tests of the mechanisms of multiregional communication. Recent mechanistic insights into brain network function also suggest new therapies to treat disordered brain networks. Here, we discuss how to use the concept of communication channel modulation can help define and constrain what we mean by multiregional communication. We discuss behavioral and neurophysiological evidence for multiregional channels modulation. We then consider the role of causal manipulations and their implications for developing novel therapies based on multiregional communication.

Original languageEnglish (US)
Pages (from-to)250-257
Number of pages8
JournalCurrent Opinion in Neurobiology
StatePublished - Feb 2021

ASJC Scopus subject areas

  • General Neuroscience


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