Multistep microchemical synthesis enabled by microfluidic distillation

Ryan L. Hartman, John R. Naber, Stephen L. Buchwald, Klavs F. Jensen

Research output: Contribution to journalArticle

Abstract

(Figure Presented) Microchemical solvent switch: A continuous-flow, multistep Heck synthesis was made possible by integrating microreactors, liquid-liquid extraction, and microfluidic distillation. The microfluidic distil-lation enabled solvent exchange from CH2CI2 in the first reaction step to N,Ndimethylformamide (DMF) in the final reaction step.

Original languageEnglish (US)
Pages (from-to)899-903
Number of pages5
JournalAngewandte Chemie - International Edition
Volume49
Issue number5
DOIs
StatePublished - Jan 25 2010

Keywords

  • Heck reaction
  • Microfluidic distillation
  • Microreactors
  • Palladium
  • Synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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