Multistep microchemical synthesis enabled by microfluidic distillation

Ryan L. Hartman; John R. Naber; Stephen L. Buchwald; Klavs F. Jensen

doi:10.1002/anie.200904634

Multistep microchemical synthesis enabled by microfluidic distillation

Ryan L. Hartman, John R. Naber, Stephen L. Buchwald, Klavs F. Jensen

Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

(Figure Presented) Microchemical solvent switch: A continuous-flow, multistep Heck synthesis was made possible by integrating microreactors, liquid-liquid extraction, and microfluidic distillation. The microfluidic distil-lation enabled solvent exchange from CH₂CI₂ in the first reaction step to N,Ndimethylformamide (DMF) in the final reaction step.

Original language	English (US)
Pages (from-to)	899-903
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	5
DOIs	https://doi.org/10.1002/anie.200904634
State	Published - Jan 25 2010

Keywords

Heck reaction
Microfluidic distillation
Microreactors
Palladium
Synthetic methods

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200904634

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abstract = "(Figure Presented) Microchemical solvent switch: A continuous-flow, multistep Heck synthesis was made possible by integrating microreactors, liquid-liquid extraction, and microfluidic distillation. The microfluidic distil-lation enabled solvent exchange from CH2CI2 in the first reaction step to N,Ndimethylformamide (DMF) in the final reaction step.",

keywords = "Heck reaction, Microfluidic distillation, Microreactors, Palladium, Synthetic methods",

author = "Hartman, {Ryan L.} and Naber, {John R.} and Buchwald, {Stephen L.} and Jensen, {Klavs F.}",

year = "2010",

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AU - Naber, John R.

AU - Buchwald, Stephen L.

AU - Jensen, Klavs F.

PY - 2010/1/25

Y1 - 2010/1/25

N2 - (Figure Presented) Microchemical solvent switch: A continuous-flow, multistep Heck synthesis was made possible by integrating microreactors, liquid-liquid extraction, and microfluidic distillation. The microfluidic distil-lation enabled solvent exchange from CH2CI2 in the first reaction step to N,Ndimethylformamide (DMF) in the final reaction step.

AB - (Figure Presented) Microchemical solvent switch: A continuous-flow, multistep Heck synthesis was made possible by integrating microreactors, liquid-liquid extraction, and microfluidic distillation. The microfluidic distil-lation enabled solvent exchange from CH2CI2 in the first reaction step to N,Ndimethylformamide (DMF) in the final reaction step.

KW - Heck reaction

KW - Microfluidic distillation

KW - Microreactors

KW - Palladium

KW - Synthetic methods

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Multistep microchemical synthesis enabled by microfluidic distillation

Abstract

Keywords

ASJC Scopus subject areas

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