Multivalent antimicrobial peptides from a reactive polymer scaffold

Zhigang Liu, Heather Deshazer, Amanda J. Rice, Kang Chen, Chunhui Zhou, Neville R. Kallenbach

Research output: Contribution to journalArticlepeer-review

Abstract

We report an application of the principle of multivalency to create new antimicrobial agents using the reactive polymaleic anhydride (PMA) chain to link antimicrobial tetrapeptides to afford multivalent variants containing ∼40 monomer units. Relative to the free peptides, the product shows a 10-fold improvement in IC50 without provoking more severe hemolysis of red blood cells. Thus, multivalency or poly valency may offer a route to enhance the activity of antimicrobial peptides.

Original languageEnglish (US)
Pages (from-to)3436-3439
Number of pages4
JournalJournal of Medicinal Chemistry
Volume49
Issue number12
DOIs
StatePublished - Jun 15 2006

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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