Multivalent antimicrobial peptides from a reactive polymer scaffold

Zhigang Liu; Heather Deshazer; Amanda J. Rice; Kang Chen; Chunhui Zhou; Neville R. Kallenbach

doi:10.1021/jm0601452

Multivalent antimicrobial peptides from a reactive polymer scaffold

Zhigang Liu, Heather Deshazer, Amanda J. Rice, Kang Chen, Chunhui Zhou, Neville R. Kallenbach

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

We report an application of the principle of multivalency to create new antimicrobial agents using the reactive polymaleic anhydride (PMA) chain to link antimicrobial tetrapeptides to afford multivalent variants containing ∼40 monomer units. Relative to the free peptides, the product shows a 10-fold improvement in IC₅₀ without provoking more severe hemolysis of red blood cells. Thus, multivalency or poly valency may offer a route to enhance the activity of antimicrobial peptides.

Original language	English (US)
Pages (from-to)	3436-3439
Number of pages	4
Journal	Journal of Medicinal Chemistry
Volume	49
Issue number	12
DOIs	https://doi.org/10.1021/jm0601452
State	Published - Jun 15 2006

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1021/jm0601452

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AU - Kallenbach, Neville R.

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Multivalent antimicrobial peptides from a reactive polymer scaffold

Abstract

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