Multivalent protein binding and precipitation by self-assembling molecules on a DNA pentaplex scaffold

Brooke A. Rosenzweig, Nathan T. Ross, Debarati M. Tagore, Janarthanan Jayawickramarajah, Ishu Saraogi, Andrew D. Hamilton

Research output: Contribution to journalArticlepeer-review

Abstract

A supramolecular assembly containing an isoguanosine pentaplex with both a "protein-binding" face and a "reporter" face has been generated. When phosphocholine is appended to the proteinbinding face this supramolecular assembly binds multivalently to the pentameric human C-reactive protein, a biomolecule implicated in inflammation and heart disease.

Original languageEnglish (US)
Pages (from-to)5020-5021
Number of pages2
JournalJournal of the American Chemical Society
Volume131
Issue number14
DOIs
StatePublished - Apr 15 2009

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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