Multivariate logistic regression for familial aggregation of two disorders. I. Development of models and methods

James I. Hudson, Nan M. Laird, Rebecca A. Betensky

Research output: Contribution to journalArticle

Abstract

The question of whether two disorders cluster together, or coaggregate, within families often arises. This paper considers how to analyze familial aggregation of two disorders and presents two multivariate logistic regression methods that model both disorder outcomes simultaneously. The first, a proband predictive model, predicts a relative's outcomes (the presence or absence of each of the two disorders) by using the proband's disorder status. The second, a family predictive model derived from the quadratic exponential model, predicts a family member's outcomes by using all of the remaining family members' disorder statuses. The models are more realistic, flexible, and powerful than univariate models. Methods for estimation and testing account for the correlation of outcomes among family members and can be implemented by using commercial software.

Original languageEnglish (US)
Pages (from-to)500-505
Number of pages6
JournalAmerican Journal of Epidemiology
Volume153
Issue number5
DOIs
StatePublished - Mar 1 2001

Keywords

  • Family
  • Family characteristics
  • Generalized estimating equation
  • Logistic models

ASJC Scopus subject areas

  • Epidemiology

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