Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice

Lisa Héron-Milhavet, Martin Haluzik, Shoshana Yakar, Oksana Gavrilova, Stephanie Pack, William C. Jou, Azeddine Ibrahimi, Hyunsook Kim, Desmond Hunt, Daphne Yau, Zeenat Asghar, Jamie Joseph, Michael B. Wheeler, Nada A. Abumrad, Derek LeRoith

Research output: Contribution to journalArticlepeer-review

Abstract

Insulin resistance is one of the primary characteristics of type 2 diabetes. Mice overespressing a dominant-negative IGF-I receptor specifically in muscle (MKR mice) demonstrate severe insulin resistance with high levels of serum and tissue lipids and eventually develop type 2 diabetes at 5-6 wk of age. To determine whether lipotoxicity plays a role in the progression of the disease, we crossed MKR mice with mice overexpressing a fatty acid translocase, CD36, in skeletal muscle. The double-transgenic MKR/CD36 mice showed normalization of the hyperglycemia and the hyperinsulinemia as well as a marked improvement in liver insulin sensitivity. The MKR/ CD36 mice also exhibited normal rates of fatty acid oxidation in skeletal muscle when compared with the decreased rate of fatty acid oxidation in MKR. With the reduction in insulin resistance, β-cell function returned to normal. These and other results suggest that the insulin resistance in the MKR mice is associated with increased muscle triglycerides levels and that whole-body insulin resistance can be, at least partially, reversed in association with a reduction in muscle triglycerides levels, although the mechanisms are yet to be determined.

Original languageEnglish (US)
Pages (from-to)4667-4676
Number of pages10
JournalEndocrinology
Volume145
Issue number10
DOIs
StatePublished - Oct 2004

ASJC Scopus subject areas

  • Endocrinology

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