Music Upper Limb Therapy-Integrated Provides a Feasible Enriched Environment and Reduces Post-stroke Depression: A Pilot Randomized Controlled Trial

Anna Palumbo, Viswanath Aluru, Jessica Battaglia, Daniel Geller, Alan Turry, Marc Ross, Adrian Cristian, Caitlin Balagula, Gbenga Ogedegbe, Latika Khatri, Moses V. Chao, Robert C. Froemke, Jacek K. Urbanek, Preeti Raghavan

Research output: Contribution to journalArticlepeer-review

Abstract

Objective This study's aims were to refine Music Upper Limb Therapy-Integrated (MULT-I) to create a feasible enriched environment for stroke rehabilitation and compare its biologic and behavioral effects with that of a home exercise program (HEP). Design This was a randomized mixed-methods study of 30 adults with post-stroke hemiparesis. Serum brain-derived neurotrophic factor and oxytocin levels measured biologic effects, and upper limb function, disability, quality of life, and emotional well-being were assessed as behavioral outcomes. Participant experiences were explored using semistructured interviews. Results MULT-I participants showed reduced depression from preintervention to postintervention as compared with HEP participants. Brain-derived neurotrophic factor levels significantly increased for MULT-I participants but decreased for HEP participants, with a significant difference between groups after excluding those with post-stroke depression. MULT-I participants additionally improved quality of life and self-perceived physical strength, mobility, activity, participation, and recovery from preintervention to postintervention. HEP participants improved upper limb function. Qualitatively, MULT-I provided psychosocial support and enjoyment, whereas HEP supported self-management of rehabilitation. Conclusions Implementation of a music-enriched environment is feasible, reduces post-stroke depression, and may enhance the neural environment for recovery via increases in brain-derived neurotrophic factor levels. Self-management of rehabilitation through an HEP may further improve upper limb function.

Original languageEnglish (US)
Pages (from-to)937-946
Number of pages10
JournalAmerican Journal of Physical Medicine and Rehabilitation
Volume101
Issue number10
DOIs
StatePublished - Oct 1 2022

Keywords

  • Enriched Environment
  • Music Therapy
  • Post-Stroke Depression (PSD)
  • Stroke

ASJC Scopus subject areas

  • Medicine(all)

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