TY - JOUR
T1 - Music Upper Limb Therapy-Integrated Provides a Feasible Enriched Environment and Reduces Post-stroke Depression
T2 - A Pilot Randomized Controlled Trial
AU - Palumbo, Anna
AU - Aluru, Viswanath
AU - Battaglia, Jessica
AU - Geller, Daniel
AU - Turry, Alan
AU - Ross, Marc
AU - Cristian, Adrian
AU - Balagula, Caitlin
AU - Ogedegbe, Gbenga
AU - Khatri, Latika
AU - Chao, Moses V.
AU - Froemke, Robert C.
AU - Urbanek, Jacek K.
AU - Raghavan, Preeti
N1 - Funding Information:
This research was supported in part by New York University Clinical Translational Science Award UL1TR000038 from the National Center for Advancing Translational Sciences (NCATS) and U54NS081765, National Institutes of Health, and in part by grants from the GRAMMY Foundation and the John and Jennifer Clay Foundation.
Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.
PY - 2022/10/1
Y1 - 2022/10/1
N2 - Objective This study's aims were to refine Music Upper Limb Therapy-Integrated (MULT-I) to create a feasible enriched environment for stroke rehabilitation and compare its biologic and behavioral effects with that of a home exercise program (HEP). Design This was a randomized mixed-methods study of 30 adults with post-stroke hemiparesis. Serum brain-derived neurotrophic factor and oxytocin levels measured biologic effects, and upper limb function, disability, quality of life, and emotional well-being were assessed as behavioral outcomes. Participant experiences were explored using semistructured interviews. Results MULT-I participants showed reduced depression from preintervention to postintervention as compared with HEP participants. Brain-derived neurotrophic factor levels significantly increased for MULT-I participants but decreased for HEP participants, with a significant difference between groups after excluding those with post-stroke depression. MULT-I participants additionally improved quality of life and self-perceived physical strength, mobility, activity, participation, and recovery from preintervention to postintervention. HEP participants improved upper limb function. Qualitatively, MULT-I provided psychosocial support and enjoyment, whereas HEP supported self-management of rehabilitation. Conclusions Implementation of a music-enriched environment is feasible, reduces post-stroke depression, and may enhance the neural environment for recovery via increases in brain-derived neurotrophic factor levels. Self-management of rehabilitation through an HEP may further improve upper limb function.
AB - Objective This study's aims were to refine Music Upper Limb Therapy-Integrated (MULT-I) to create a feasible enriched environment for stroke rehabilitation and compare its biologic and behavioral effects with that of a home exercise program (HEP). Design This was a randomized mixed-methods study of 30 adults with post-stroke hemiparesis. Serum brain-derived neurotrophic factor and oxytocin levels measured biologic effects, and upper limb function, disability, quality of life, and emotional well-being were assessed as behavioral outcomes. Participant experiences were explored using semistructured interviews. Results MULT-I participants showed reduced depression from preintervention to postintervention as compared with HEP participants. Brain-derived neurotrophic factor levels significantly increased for MULT-I participants but decreased for HEP participants, with a significant difference between groups after excluding those with post-stroke depression. MULT-I participants additionally improved quality of life and self-perceived physical strength, mobility, activity, participation, and recovery from preintervention to postintervention. HEP participants improved upper limb function. Qualitatively, MULT-I provided psychosocial support and enjoyment, whereas HEP supported self-management of rehabilitation. Conclusions Implementation of a music-enriched environment is feasible, reduces post-stroke depression, and may enhance the neural environment for recovery via increases in brain-derived neurotrophic factor levels. Self-management of rehabilitation through an HEP may further improve upper limb function.
KW - Enriched Environment
KW - Music Therapy
KW - Post-Stroke Depression (PSD)
KW - Stroke
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U2 - 10.1097/PHM.0000000000001938
DO - 10.1097/PHM.0000000000001938
M3 - Article
C2 - 34864768
AN - SCOPUS:85128196002
VL - 101
SP - 937
EP - 946
JO - American Journal of Physical Medicine
JF - American Journal of Physical Medicine
SN - 0894-9115
IS - 10
ER -