N-Naphthyl peptoid foldamers exhibiting atropisomerism

Bishwajit Paul, Glenn L. Butterfoss, Mikki G. Boswell, Mia L. Huang, Richard Bonneau, Christian Wolf, Kent Kirshenbaum

Research output: Contribution to journalArticle

Abstract

We introduce peptoid oligomers incorporating N-(1)-naphthyl glycine monomers. Axial chirality was established due to restricted rotation about the C - N(aryl) bond. Atropisomerism of both linear and cyclic peptoids was investigated by computational analysis, dynamic HPLC, and X-ray crystallographic studies.

Original languageEnglish (US)
Pages (from-to)926-929
Number of pages4
JournalOrganic Letters
Volume14
Issue number3
DOIs
StatePublished - Feb 3 2012

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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