Nano hydroxyapatite-coated implants improve bone nanomechanical properties

R. Jimbo, P. G. Coelho, M. Bryington, M. Baldassarri, N. Tovar, F. Currie, M. Hayashi, M. N. Janal, M. Andersson, D. Ono, S. Vandeweghe, A. Wennerberg

Research output: Contribution to journalArticlepeer-review


Nanostructure modification of dental implants has long been sought as a means to improve osseointegration through enhanced biomimicry of host structures. Several methods have been proposed and demonstrated for creating nanotopographic features; here we describe a nanoscale hydroxyapatite (HA)-coated implant surface and hypothesize that it will hasten osseointegration and improve its quality relative to that of non-coated implants. Twenty threaded titanium alloy implants, half prepared with a stable HA nanoparticle surface and half grit-blasted, acid-etched, and heat-treated (HT), were inserted into rabbit femurs. Pre-operatively, the implants were morphologically and topographically characterized. After 3 weeks of healing, the samples were retrieved for histomorphometry. The nanomechanical properties of the surrounding bone were evaluated by nanoindentation. While both implants revealed similar bone-to-implant contact, the nanoindentation demonstrated that the tissue quality was significantly enhanced around the HA-coated implants, validating the postulated hypothesis.

Original languageEnglish (US)
Pages (from-to)1172-1177
Number of pages6
JournalJournal of dental research
Issue number12
StatePublished - Dec 2012


  • biomechanics
  • calcium phosphate
  • dental implants
  • histology
  • nanostructures
  • osseointegration

ASJC Scopus subject areas

  • General Dentistry


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