Nanofluidic concentration devices for biomolecules utilizing ion concentration polarization: Theory, fabrication, and applications

Sung Jae Kim, Yong Ak Song, Jongyoon Han

Research output: Contribution to journalArticlepeer-review

Abstract

Recently, a new type of electrokinetic concentration devices has been developed in a microfluidic chip format, which allows efficient trapping and concentration of biomolecules by utilizing ion concentration polarization near nanofluidic structures. These devices have drawn much attention not only due to their potential application in biomolecule sensing, but also due to the rich scientific content related to ion concentration polarization, the underlying physical phenomenon for the operation of these electrokinetic concentration devices. This tutorial review provides an introduction to the scientific and engineering advances achieved, in-depth discussion about several interesting applications of these unique concentration devices, and their current limitations and challenges.

Original languageEnglish (US)
Pages (from-to)912-922
Number of pages11
JournalChemical Society Reviews
Volume39
Issue number3
DOIs
StatePublished - Feb 24 2010

ASJC Scopus subject areas

  • Chemistry(all)

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