Nanopatterned Bulk Metallic Glass Biosensors

Emily R. Kinser, Jagannath Padmanabhan, Roy Yu, Sydney L. Corona, Jinyang Li, Sagar Vaddiraju, Allen Legassey, Ayomiposi Loye, Jenna Balestrini, Dawson A. Solly, Jan Schroers, André D. Taylor, Fotios Papadimitrakopoulos, Raimund I. Herzog, Themis R. Kyriakides

Research output: Contribution to journalArticle

Abstract

Nanopatterning as a surface area enhancement method has the potential to increase signal and sensitivity of biosensors. Platinum-based bulk metallic glass (Pt-BMG) is a biocompatible material with electrical properties conducive for biosensor electrode applications, which can be processed in air at comparably low temperatures to produce nonrandom topography at the nanoscale. Work presented here employs nanopatterned Pt-BMG electrodes functionalized with glucose oxidase enzyme to explore the impact of nonrandom and highly reproducible nanoscale surface area enhancement on glucose biosensor performance. Electrochemical measurements including cyclic voltammetry (CV) and amperometric voltammetry (AV) were completed to compare the performance of 200 nm Pt-BMG electrodes vs Flat Pt-BMG control electrodes. Glucose dosing response was studied in a range of 2 mM to 10 mM. Effective current density dynamic range for the 200 nm Pt-BMG was 10-12 times greater than that of the Flat BMG control. Nanopatterned electrode sensitivity was measured to be 3.28 μA/cm2/mM, which was also an order of magnitude greater than the flat electrode. These results suggest that nonrandom nanotopography is a scalable and customizable engineering tool which can be integrated with Pt-BMGs to produce biocompatible biosensors with enhanced signal and sensitivity.

Original languageEnglish (US)
Pages (from-to)1779-1787
Number of pages9
JournalACS Sensors
Volume2
Issue number12
DOIs
StatePublished - Dec 22 2017

Keywords

  • biomaterials
  • bulk metallic glass
  • electrochemical biosensor
  • nanorods
  • nanotopography

ASJC Scopus subject areas

  • Bioengineering
  • Instrumentation
  • Process Chemistry and Technology
  • Fluid Flow and Transfer Processes

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  • Cite this

    Kinser, E. R., Padmanabhan, J., Yu, R., Corona, S. L., Li, J., Vaddiraju, S., Legassey, A., Loye, A., Balestrini, J., Solly, D. A., Schroers, J., Taylor, A. D., Papadimitrakopoulos, F., Herzog, R. I., & Kyriakides, T. R. (2017). Nanopatterned Bulk Metallic Glass Biosensors. ACS Sensors, 2(12), 1779-1787. https://doi.org/10.1021/acssensors.7b00455