Nanoroughened surfaces for efficient capture of circulating tumor cells without using capture antibodies

Weiqiang Chen, Shinuo Weng, Feng Zhang, Steven Allen, Xiang Li, Liwei Bao, Raymond H.W. Lam, Jill A. MacOska, Sofia D. Merajver, Jianping Fu

Research output: Contribution to journalArticlepeer-review

Abstract

Circulating tumor cells (CTCs) detached from both primary and metastatic lesions represent a potential alternative to invasive biopsies as a source of tumor tissue for the detection, characterization and monitoring of cancers. Here we report a simple yet effective strategy for capturing CTCs without using capture antibodies. Our method uniquely utilized the differential adhesion preference of cancer cells to nanorough surfaces when compared to normal blood cells and thus did not depend on their physical size or surface protein expression, a significant advantage as compared to other existing CTC capture techniques.

Original languageEnglish (US)
Pages (from-to)566-575
Number of pages10
JournalACS nano
Volume7
Issue number1
DOIs
StatePublished - Jan 22 2013

Keywords

  • biomaterials
  • cancer
  • circulating tumor cell
  • microfabrication
  • nanotopography

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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