Nanostructure of Materials Determined by Relayed Paramagnetic Relaxation Enhancement

Judith Schlagnitweit, Mingxue Tang, Maria Baias, Sara Richardson, Staffan Schantz, Lyndon Emsley

Research output: Contribution to journalArticlepeer-review

Abstract

Particle and domain sizes strongly influence the properties of materials. Here we present an NMR approach based on paramagnetic relaxation enhancement (PRE) relayed by spin diffusion (SD), which allows us to determine lengths in the nm-μm range. We demonstrate the method on multicomponent organic polymer mixtures by selectively doping one component with a paramagnetic center in order to measure the domain size in a second component. Using this approach we determine domain sizes in ethyl cellulose/hydroxypropyl cellulose film coatings in pharmaceutical controlled release formulations. Here we measure particle sizes ranging from around 50 to 200 nm.

Original languageEnglish (US)
Pages (from-to)12482-12485
Number of pages4
JournalJournal of the American Chemical Society
Volume137
Issue number39
DOIs
StatePublished - Oct 7 2015

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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