Nanostructure of Materials Determined by Relayed Paramagnetic Relaxation Enhancement

Judith Schlagnitweit; Mingxue Tang; Maria Baias; Sara Richardson; Staffan Schantz; Lyndon Emsley

doi:10.1021/jacs.5b08249

Nanostructure of Materials Determined by Relayed Paramagnetic Relaxation Enhancement

Judith Schlagnitweit, Mingxue Tang, Maria Baias, Sara Richardson, Staffan Schantz, Lyndon Emsley

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Particle and domain sizes strongly influence the properties of materials. Here we present an NMR approach based on paramagnetic relaxation enhancement (PRE) relayed by spin diffusion (SD), which allows us to determine lengths in the nm-μm range. We demonstrate the method on multicomponent organic polymer mixtures by selectively doping one component with a paramagnetic center in order to measure the domain size in a second component. Using this approach we determine domain sizes in ethyl cellulose/hydroxypropyl cellulose film coatings in pharmaceutical controlled release formulations. Here we measure particle sizes ranging from around 50 to 200 nm.

Original language	English (US)
Pages (from-to)	12482-12485
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	137
Issue number	39
DOIs	https://doi.org/10.1021/jacs.5b08249
State	Published - Oct 7 2015

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/jacs.5b08249

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title = "Nanostructure of Materials Determined by Relayed Paramagnetic Relaxation Enhancement",

abstract = "Particle and domain sizes strongly influence the properties of materials. Here we present an NMR approach based on paramagnetic relaxation enhancement (PRE) relayed by spin diffusion (SD), which allows us to determine lengths in the nm-μm range. We demonstrate the method on multicomponent organic polymer mixtures by selectively doping one component with a paramagnetic center in order to measure the domain size in a second component. Using this approach we determine domain sizes in ethyl cellulose/hydroxypropyl cellulose film coatings in pharmaceutical controlled release formulations. Here we measure particle sizes ranging from around 50 to 200 nm.",

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AU - Schantz, Staffan

AU - Emsley, Lyndon

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N2 - Particle and domain sizes strongly influence the properties of materials. Here we present an NMR approach based on paramagnetic relaxation enhancement (PRE) relayed by spin diffusion (SD), which allows us to determine lengths in the nm-μm range. We demonstrate the method on multicomponent organic polymer mixtures by selectively doping one component with a paramagnetic center in order to measure the domain size in a second component. Using this approach we determine domain sizes in ethyl cellulose/hydroxypropyl cellulose film coatings in pharmaceutical controlled release formulations. Here we measure particle sizes ranging from around 50 to 200 nm.

AB - Particle and domain sizes strongly influence the properties of materials. Here we present an NMR approach based on paramagnetic relaxation enhancement (PRE) relayed by spin diffusion (SD), which allows us to determine lengths in the nm-μm range. We demonstrate the method on multicomponent organic polymer mixtures by selectively doping one component with a paramagnetic center in order to measure the domain size in a second component. Using this approach we determine domain sizes in ethyl cellulose/hydroxypropyl cellulose film coatings in pharmaceutical controlled release formulations. Here we measure particle sizes ranging from around 50 to 200 nm.

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Nanostructure of Materials Determined by Relayed Paramagnetic Relaxation Enhancement

Abstract

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