Nanotopographic control of human embryonic stem cell function

W. Chen, Y. Sun, J. Fu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Human embryonic stem cells (hESCs) exhibit diverse behaviors responding to their microenvironment. Here we developed an effective method for precise control of local nanoroughness on glass substrates using the reactive ion etching (RIE) and photolithography techniques. We for the first time demonstrated that the local nanoroughness could mediate hESC functions, including morphology, attachment, proliferation and differentiation.

Original languageEnglish (US)
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages36-38
Number of pages3
StatePublished - 2011
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: Oct 2 2011Oct 6 2011

Publication series

Name15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Volume1

Other

Other15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
CountryUnited States
CitySeattle, WA
Period10/2/1110/6/11

Keywords

  • Extracellular matrix
  • Human embryonic stem cell
  • Nanoroughness
  • Nanotopography

ASJC Scopus subject areas

  • Control and Systems Engineering

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