Naturalistic conceptions of genetic optimism and precision psychiatry among those at clinical high-risk for psychosis

Drew Blasco; Saige William Stortz; Margaux Marie Rose Grivel; Gabriella A. Dishy; Shana S. Samuel; David Pilla; Francesca M. Crump; Sarah A. Lieff; Jourdan Williams; Phetsamone Phoummavong; Xufei Guo; Gary Brucato; Ragy R. Girgis; Lawrence H. Yang

doi:10.1111/eip.12983

Naturalistic conceptions of genetic optimism and precision psychiatry among those at clinical high-risk for psychosis

Drew Blasco, Saige William Stortz, Margaux Marie Rose Grivel, Gabriella A. Dishy, Shana S. Samuel, David Pilla, Francesca M. Crump, Sarah A. Lieff, Jourdan Williams, Phetsamone Phoummavong, Xufei Guo, Gary Brucato, Ragy R. Girgis, Lawrence H. Yang

Global Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: Fuelled by genomics advances, recent emphasis on the concept of “precision medicine,” and public optimism towards genetic advances, it is important to understand how those who are considered to be at clinical high-risk for psychosis (CHR) perceive possible benefits of genetic testing to inform future stakeholder education efforts. Methods: Semistructured interviews were completed with 20 participants who met CHR criteria. Coding for genetic optimism was completed. Results: Participants endorsed many conceptualizations of the link between genetics, the development of psychosis, and the benefits of genetic testing. Specifically, themes emerged surrounding how genetic testing may lead to greater genetic knowledge and tailored treatment. Conclusions: Our results demonstrate that CHR participants generally endorse several precision psychiatry concepts, including how genetic testing may lead to tailored treatment advances. This knowledge may aid development of best communication practices regarding forthcoming genetic advances in diagnosis and treatment among CHR.

Original language	English (US)
Pages (from-to)	742-745
Number of pages	4
Journal	Early Intervention in Psychiatry
Volume	15
Issue number	3
DOIs	https://doi.org/10.1111/eip.12983
State	Published - Jun 2021

Keywords

clinical high-risk
genetic optimism
genetic testing
precision medicine
psychotic disorders

ASJC Scopus subject areas

Phychiatric Mental Health
Psychiatry and Mental health
Biological Psychiatry

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10.1111/eip.12983

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Blasco, D., Stortz, S. W., Grivel, M. M. R., Dishy, G. A., Samuel, S. S., Pilla, D., Crump, F. M., Lieff, S. A., Williams, J., Phoummavong, P., Guo, X., Brucato, G., Girgis, R. R., & Yang, L. H. (2021). Naturalistic conceptions of genetic optimism and precision psychiatry among those at clinical high-risk for psychosis. Early Intervention in Psychiatry, 15(3), 742-745. https://doi.org/10.1111/eip.12983

Blasco, D, Stortz, SW, Grivel, MMR, Dishy, GA, Samuel, SS, Pilla, D, Crump, FM, Lieff, SA, Williams, J, Phoummavong, P, Guo, X, Brucato, G, Girgis, RR & Yang, LH 2021, 'Naturalistic conceptions of genetic optimism and precision psychiatry among those at clinical high-risk for psychosis', Early Intervention in Psychiatry, vol. 15, no. 3, pp. 742-745. https://doi.org/10.1111/eip.12983

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abstract = "Aim: Fuelled by genomics advances, recent emphasis on the concept of “precision medicine,” and public optimism towards genetic advances, it is important to understand how those who are considered to be at clinical high-risk for psychosis (CHR) perceive possible benefits of genetic testing to inform future stakeholder education efforts. Methods: Semistructured interviews were completed with 20 participants who met CHR criteria. Coding for genetic optimism was completed. Results: Participants endorsed many conceptualizations of the link between genetics, the development of psychosis, and the benefits of genetic testing. Specifically, themes emerged surrounding how genetic testing may lead to greater genetic knowledge and tailored treatment. Conclusions: Our results demonstrate that CHR participants generally endorse several precision psychiatry concepts, including how genetic testing may lead to tailored treatment advances. This knowledge may aid development of best communication practices regarding forthcoming genetic advances in diagnosis and treatment among CHR.",

keywords = "clinical high-risk, genetic optimism, genetic testing, precision medicine, psychotic disorders",

author = "Drew Blasco and Stortz, {Saige William} and Grivel, {Margaux Marie Rose} and Dishy, {Gabriella A.} and Samuel, {Shana S.} and David Pilla and Crump, {Francesca M.} and Lieff, {Sarah A.} and Jourdan Williams and Phetsamone Phoummavong and Xufei Guo and Gary Brucato and Girgis, {Ragy R.} and Yang, {Lawrence H.}",

note = "Publisher Copyright: {\textcopyright} 2020 John Wiley & Sons Australia, Ltd",

year = "2021",

month = jun,

doi = "10.1111/eip.12983",

language = "English (US)",

volume = "15",

pages = "742--745",

journal = "Early Intervention in Psychiatry",

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AU - Blasco, Drew

AU - Stortz, Saige William

AU - Grivel, Margaux Marie Rose

AU - Dishy, Gabriella A.

AU - Samuel, Shana S.

AU - Pilla, David

AU - Crump, Francesca M.

AU - Lieff, Sarah A.

AU - Williams, Jourdan

AU - Phoummavong, Phetsamone

AU - Guo, Xufei

AU - Brucato, Gary

AU - Girgis, Ragy R.

AU - Yang, Lawrence H.

PY - 2021/6

Y1 - 2021/6

N2 - Aim: Fuelled by genomics advances, recent emphasis on the concept of “precision medicine,” and public optimism towards genetic advances, it is important to understand how those who are considered to be at clinical high-risk for psychosis (CHR) perceive possible benefits of genetic testing to inform future stakeholder education efforts. Methods: Semistructured interviews were completed with 20 participants who met CHR criteria. Coding for genetic optimism was completed. Results: Participants endorsed many conceptualizations of the link between genetics, the development of psychosis, and the benefits of genetic testing. Specifically, themes emerged surrounding how genetic testing may lead to greater genetic knowledge and tailored treatment. Conclusions: Our results demonstrate that CHR participants generally endorse several precision psychiatry concepts, including how genetic testing may lead to tailored treatment advances. This knowledge may aid development of best communication practices regarding forthcoming genetic advances in diagnosis and treatment among CHR.

AB - Aim: Fuelled by genomics advances, recent emphasis on the concept of “precision medicine,” and public optimism towards genetic advances, it is important to understand how those who are considered to be at clinical high-risk for psychosis (CHR) perceive possible benefits of genetic testing to inform future stakeholder education efforts. Methods: Semistructured interviews were completed with 20 participants who met CHR criteria. Coding for genetic optimism was completed. Results: Participants endorsed many conceptualizations of the link between genetics, the development of psychosis, and the benefits of genetic testing. Specifically, themes emerged surrounding how genetic testing may lead to greater genetic knowledge and tailored treatment. Conclusions: Our results demonstrate that CHR participants generally endorse several precision psychiatry concepts, including how genetic testing may lead to tailored treatment advances. This knowledge may aid development of best communication practices regarding forthcoming genetic advances in diagnosis and treatment among CHR.

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Naturalistic conceptions of genetic optimism and precision psychiatry among those at clinical high-risk for psychosis

Abstract

Keywords

ASJC Scopus subject areas

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