Naturalistic conceptions of genetic optimism and precision psychiatry among those at clinical high-risk for psychosis

Drew Blasco, Saige William Stortz, Margaux Marie Rose Grivel, Gabriella A. Dishy, Shana S. Samuel, David Pilla, Francesca M. Crump, Sarah A. Lieff, Jourdan Williams, Phetsamone Phoummavong, Xufei Guo, Gary Brucato, Ragy R. Girgis, Lawrence H. Yang

Research output: Contribution to journalArticlepeer-review


Aim: Fuelled by genomics advances, recent emphasis on the concept of “precision medicine,” and public optimism towards genetic advances, it is important to understand how those who are considered to be at clinical high-risk for psychosis (CHR) perceive possible benefits of genetic testing to inform future stakeholder education efforts. Methods: Semistructured interviews were completed with 20 participants who met CHR criteria. Coding for genetic optimism was completed. Results: Participants endorsed many conceptualizations of the link between genetics, the development of psychosis, and the benefits of genetic testing. Specifically, themes emerged surrounding how genetic testing may lead to greater genetic knowledge and tailored treatment. Conclusions: Our results demonstrate that CHR participants generally endorse several precision psychiatry concepts, including how genetic testing may lead to tailored treatment advances. This knowledge may aid development of best communication practices regarding forthcoming genetic advances in diagnosis and treatment among CHR.

Original languageEnglish (US)
Pages (from-to)742-745
Number of pages4
JournalEarly Intervention in Psychiatry
Issue number3
StatePublished - Jun 2021


  • clinical high-risk
  • genetic optimism
  • genetic testing
  • precision medicine
  • psychotic disorders

ASJC Scopus subject areas

  • Phychiatric Mental Health
  • Psychiatry and Mental health
  • Biological Psychiatry


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