Near quantitative production of molecular nitrogen from metabolism of dimethylnitrosamine

S. Milstein, J. B. Guttenplan

Research output: Contribution to journalArticlepeer-review


Molecular nitrogen is produced stoichiometrically from the spontaneous decomposition of N-methyl-N-nitrosourea in phosphate buffer and is readily detected by gas chromatography. It is also generated in high yield from the oxidation of dimethylnitrosamine by mouse or rat liver microsomes. Gas chromatographic analysis for nitrogen generated from dimethylnitrosamine was more difficult because the amount of nitrogen generated was similar to that produced in control tubes which contained no dimethylnitrosamine.

Original languageEnglish (US)
Pages (from-to)337-342
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number1
StatePublished - Mar 15 1979

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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