Necrotizing fasciitis associated with malignancy

Leon L. Chen, Kate Tayban, Christopher Caravanos, David Shaz, Neil A. Halpern

Research output: Contribution to journalArticlepeer-review


Necrotizing fasciitis (NF) is a rare soft-tissue condition with a high mortality rate even with treatment. Diagnosis is challenging due to an absence of specific symptoms at the early stages of clinical presentation. NF is typically associated with traumatic injuries, superficial skin breakdown, and surgical procedures. Diabetes mellitus and immunosuppression also increase the risk of developing NF. NF predominantly occurs in the lower extremities, the peritoneum, and the perineum. Treatments include antimicrobials, supportive care, and surgical source control. It is important for clinicians to recognize the association of spontaneous atraumatic NF caused by Clostridium septicum with malignancy, so they can maintain a high index of suspicion and provide timely interventions to optimize patient outcomes.

Original languageEnglish (US)
Pages (from-to)109-112
Number of pages4
JournalJournal of the American Association of Nurse Practitioners
Issue number2
StatePublished - Feb 1 2020


  • Clostridium septicum
  • Multiorgan failure
  • Necrotizing fasciitis
  • Septic shock

ASJC Scopus subject areas

  • General Nursing


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