Nerve Injury Decreases Hyperacute Resting-State Connectivity between the Anterior Cingulate and Primary Somatosensory Cortex in Anesthetized Rats

Lea Tottrup, S. Farokh Atashzar, Dario Farina, Ernest N. Kamavuako, Winnie Jensen

Research output: Contribution to journalArticlepeer-review

Abstract

A better understanding of neural pain processing and of the development of pain over time, is critical to identify objective measures of pain and to evaluate the effect of pain alleviation therapies. One issue is, that the brain areas known to be related to pain processing are not exclusively responding to painful stimuli, and the neuronal activity is also influenced by other brain areas. Functional connectivity reflects synchrony or covariation of activation between groups of neurons. Previous studies found changes in connectivity days or weeks after pain induction. However, less in known on the temporal development of pain. Our objective was therefore to investigate the interaction between the anterior cingulate cortex (ACC) and primary somatosensory cortex (SI) in the hyperacute (minute) and sustained (hours) response in an animal model of neuropathic pain. Intra-cortical local field potentials (LFP) were recorded in 18 rats. In 10 rats the spared nerve injury model was used as an intervention. The intra-cortical activity was recorded before, immediately after, and three hours after the intervention. The interaction was quantified as the calculated correlation and coherence. The results from the intervention group showed a decrease in correlation between ACC and SI activity, which was most pronounced in the hyperacute phase but a longer time frame may be required for plastic changes to occur. This indicated that both SI and ACC are involved in hyperacute pain processing.

Original languageEnglish (US)
Article number9270573
Pages (from-to)2691-2698
Number of pages8
JournalIEEE Transactions on Neural Systems and Rehabilitation Engineering
Volume28
Issue number12
DOIs
StatePublished - Dec 2020

Keywords

  • Coherence analysis
  • functional connectivity
  • invasive microelectrode recording
  • local field potentials
  • pain neurophysiology

ASJC Scopus subject areas

  • Internal Medicine
  • Neuroscience(all)
  • Biomedical Engineering

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