TY - JOUR
T1 - Networks in Caenorhabditis elegans
AU - Gunsalus, Kristin C.
AU - Rhrissorrakrai, Kahn
N1 - Funding Information:
The authors thank Fabio Piano for insightful comments on the manuscript. This work was supported by NIH grants R01-HD046236, R01-GM085503, and U01-HG004276.
PY - 2011/12
Y1 - 2011/12
N2 - The network paradigm has become a pervasive theme in biology over the last decade, as increasingly large functional genomic datasets are being collected to interrogate regulatory influences, physical interactions, and genetic dependencies between genes, transcripts, and proteins. These 'molecular interaction' networks can be analyzed collectively and individually to define their global architecture and local patterns of connectivity. These structural features ultimately underlie functional properties such as robustness, modularity, component circuitry (e.g. feedback loops), dynamics, and responses to perturbations. This review focuses on recent progress in elucidating molecular interaction networks using different kinds of functional assays in the classical genetic model for animal development, the roundworm Caenorhabditis elegans, with representative examples to illustrate current directions in different areas of network biology.
AB - The network paradigm has become a pervasive theme in biology over the last decade, as increasingly large functional genomic datasets are being collected to interrogate regulatory influences, physical interactions, and genetic dependencies between genes, transcripts, and proteins. These 'molecular interaction' networks can be analyzed collectively and individually to define their global architecture and local patterns of connectivity. These structural features ultimately underlie functional properties such as robustness, modularity, component circuitry (e.g. feedback loops), dynamics, and responses to perturbations. This review focuses on recent progress in elucidating molecular interaction networks using different kinds of functional assays in the classical genetic model for animal development, the roundworm Caenorhabditis elegans, with representative examples to illustrate current directions in different areas of network biology.
UR - http://www.scopus.com/inward/record.url?scp=81955164148&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=81955164148&partnerID=8YFLogxK
U2 - 10.1016/j.gde.2011.10.003
DO - 10.1016/j.gde.2011.10.003
M3 - Review article
C2 - 22054717
AN - SCOPUS:81955164148
SN - 0959-437X
VL - 21
SP - 787
EP - 798
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 6
ER -