Networks in Caenorhabditis elegans

Kristin C. Gunsalus, Kahn Rhrissorrakrai

Research output: Contribution to journalReview article

Abstract

The network paradigm has become a pervasive theme in biology over the last decade, as increasingly large functional genomic datasets are being collected to interrogate regulatory influences, physical interactions, and genetic dependencies between genes, transcripts, and proteins. These 'molecular interaction' networks can be analyzed collectively and individually to define their global architecture and local patterns of connectivity. These structural features ultimately underlie functional properties such as robustness, modularity, component circuitry (e.g. feedback loops), dynamics, and responses to perturbations. This review focuses on recent progress in elucidating molecular interaction networks using different kinds of functional assays in the classical genetic model for animal development, the roundworm Caenorhabditis elegans, with representative examples to illustrate current directions in different areas of network biology.

Original languageEnglish (US)
Pages (from-to)787-798
Number of pages12
JournalCurrent Opinion in Genetics and Development
Volume21
Issue number6
DOIs
StatePublished - Dec 2011

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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