Neural and endocrine correlates of sadness in women: Implications for neural network regulation of HPA activity

William E. Ottowitz, Darin D. Dougherty, Alan Sirota, Raymond Niaura, Scott L. Rauch, Walter A. Brown

Research output: Contribution to journalArticlepeer-review

Abstract

In order to evaluate the suprahypothalamic neuroanatomical sites of relevance to adrenocorticotropic hormone (ACTH) and cortisol regulation, single photon emission computed tomography (SPECT) investigation of induced sadness was combined with a linear regression analysis of these hormone levels during mood induction. Images from eight healthy women were analyzed by statistical parametric mapping (SPM), replicating many findings from prior sadness induction studies. Statistical parametric mapping endocrine covariate analysis showed that the ventromedial prefrontal, anterior cingulate, and insular cortices may regulate ACTH and the insular cortex may be related to regulation of cortisol during sadness. Dysfunction of these sites may contribute to the cortisol dysregulation observed in some subjects with major depression.

Original languageEnglish (US)
Pages (from-to)446-455
Number of pages10
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume16
Issue number4
DOIs
StatePublished - 2004

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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