TY - JOUR
T1 - Neural basis of acquired amusia and its recovery after stroke
AU - Sihvonen, Aleksi J.
AU - Ripollés, Pablo
AU - Leo, Vera
AU - Rodríguez-Fornells, Antoni
AU - Soinila, Seppo
AU - Särkämö, Teppo
N1 - Funding Information:
This work was supported by the Academy of Finland program (1257077, 1277693), Turku University Hospital Research Funding, the Finnish Brain Research and Rehabilitation Foundation, the Ella and Georg Ehrnrooth Foundation, the Signe and Ane Gyllenberg Foundation, the Finnish Cultural Foundation, the National Doctoral Programme of Psychology, the Jenny and Antti Wihuri Foundation, the Formación de Profesorado Universitario program (AP2010-4170), and the Generalitat de Catalunya (2014 SGR1413). We thank the staffs of the HUCH Department of Neurology, Turku University Hospital Department of Neurology, and other rehabilitation hospitals in the Hospital District of Southwest Finland and Helsinki metropolitan area for their collaboration.Wethank Prof. Mari Tervaniemi, Prof. Riitta Parkkola, Prof. Taina Autti, Dr. Heli Silvennoinen, Jani Saunavaara, PhD, and radiographers Ulla Anttalainen (†), Riku Luoto, Pentti Pöönen, and Tuija Vahtera. We also thank the patient subjects and their families for their participation and effort
Publisher Copyright:
© 2016 the authors.
PY - 2016/8/24
Y1 - 2016/8/24
N2 - Although acquired amusia is a relatively common disorder after stroke, its precise neuroanatomical basis is still unknown. To evaluate which brain regions form the neural substrate for acquired amusia and its recovery, we performed a voxel-based lesion-symptom mapping (VLSM) and morphometry (VBM) study with 77 human stroke subjects. Structural MRIs were acquired at acute and 6 month poststroke stages. Amusia and aphasia were behaviorally assessed at acute and 3 month poststroke stages using the Scale and Rhythm subtests of the Montreal Battery of Evaluation of Amusia (MBEA) and language tests. VLSM analyses indicated that amusia was associated with a lesion area comprising the superior temporal gyrus, Heschl’s gyrus, insula, and striatum in the right hemisphere, clearly different from the lesion pattern associated with aphasia. Parametric analyses of MBEA Pitch and Rhythm scores showed extensive lesion overlap in the right striatum, as well as in the right Heschl’s gyrus and superior temporal gyrus. Lesions associated with Rhythm scores extended more superiorly and posterolaterally. VBM analysis of volume changes from the acute to the 6 month stage showed a clear decrease in gray matter volume in the right superior and middle temporal gyri in nonrecovered amusic patients compared with nona-music patients. This increased atrophy was more evident in anterior temporal areas in rhythm amusia and in posterior temporal and temporoparietal areas in pitch amusia. Overall, the results implicate right temporal and subcortical regions as the crucial neural substrate for acquired amusia and highlight the importance of different temporal lobe regions for the recovery of amusia after stroke.
AB - Although acquired amusia is a relatively common disorder after stroke, its precise neuroanatomical basis is still unknown. To evaluate which brain regions form the neural substrate for acquired amusia and its recovery, we performed a voxel-based lesion-symptom mapping (VLSM) and morphometry (VBM) study with 77 human stroke subjects. Structural MRIs were acquired at acute and 6 month poststroke stages. Amusia and aphasia were behaviorally assessed at acute and 3 month poststroke stages using the Scale and Rhythm subtests of the Montreal Battery of Evaluation of Amusia (MBEA) and language tests. VLSM analyses indicated that amusia was associated with a lesion area comprising the superior temporal gyrus, Heschl’s gyrus, insula, and striatum in the right hemisphere, clearly different from the lesion pattern associated with aphasia. Parametric analyses of MBEA Pitch and Rhythm scores showed extensive lesion overlap in the right striatum, as well as in the right Heschl’s gyrus and superior temporal gyrus. Lesions associated with Rhythm scores extended more superiorly and posterolaterally. VBM analysis of volume changes from the acute to the 6 month stage showed a clear decrease in gray matter volume in the right superior and middle temporal gyri in nonrecovered amusic patients compared with nona-music patients. This increased atrophy was more evident in anterior temporal areas in rhythm amusia and in posterior temporal and temporoparietal areas in pitch amusia. Overall, the results implicate right temporal and subcortical regions as the crucial neural substrate for acquired amusia and highlight the importance of different temporal lobe regions for the recovery of amusia after stroke.
KW - Amusia
KW - Aphasia
KW - Music
KW - Stroke
KW - Voxel-based lesion-symptom mapping
KW - Voxel-based morphometry
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UR - http://www.scopus.com/inward/citedby.url?scp=84983266497&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.0709-16.2016
DO - 10.1523/JNEUROSCI.0709-16.2016
M3 - Article
C2 - 27559169
AN - SCOPUS:84983266497
VL - 36
SP - 8872
EP - 8881
JO - Journal of Neuroscience
JF - Journal of Neuroscience
SN - 0270-6474
IS - 34
ER -