@article{b1de30fbcb1742c782fe1c220f130757,
title = "Neural effects of controllability as a key dimension of stress exposure",
abstract = "Cross-species evidence suggests that the ability to exert control over a stressor is a key dimension of stress exposure that may sensitize frontostriatal-amygdala circuitry to promote more adaptive responses to subsequent stressors. The present study examined neural correlates of stressor controllability in young adults. Participants (N = 56; M age = 23.74, range = 18-30 years) completed either the controllable or uncontrollable stress condition of the first of two novel stressor controllability tasks during functional magnetic resonance imaging (fMRI) acquisition. Participants in the uncontrollable stress condition were yoked to age- and sex-matched participants in the controllable stress condition. All participants were subsequently exposed to uncontrollable stress in the second task, which is the focus of fMRI analyses reported here. A whole-brain searchlight classification analysis revealed that patterns of activity in the right dorsal anterior insula (dAI) during subsequent exposure to uncontrollable stress could be used to classify participants' initial exposure to either controllable or uncontrollable stress with a peak of 73% accuracy. Previous experience of exerting control over a stressor may change the computations performed within the right dAI during subsequent stress exposure, shedding further light on the neural underpinnings of stressor controllability.",
keywords = "control, frontolimbic circuitry, stress, stress reactivity, stressor controllability",
author = "Cohodes, {Emily M.} and Paola Odriozola and Mandell, {Jeffrey D.} and Camila Caballero and Sarah McCauley and Zacharek, {Sadie J.} and Hodges, {H. R.} and Haberman, {Jason T.} and MacKenzye Smith and Janeen Thomas and Meisner, {Olivia C.} and Ellis, {Cameron T.} and Hartley, {Catherine A.} and Gee, {Dylan G.}",
note = "Funding Information: This work was supported by the National Institutes of Health (NIH) Director{\textquoteright}s Early Independence Award (DP5OD021370) to D.G.G., Brain & Behavior Research Foundation (National Alliance for Research on Schizophrenia and Depression; NARSAD) Young Investigator Award to D.G.G., Jacobs Foundation Early Career Research Fellowship to D.G.G., The Society for Clinical Child and Adolescent Psychology (Division 53 of the American Psychological Association) Richard {"}Dick{"} Abidin Early Career Award and Grant to D.G.G., National Science Foundation (NSF) GRFP Awards to E.M.C. (NSF DGE1752134) and P.O. (NSF DGE-1122492), The Society for Clinical Child and Adolescent Psychology (Division 53 of the American Psychological Association) Donald Routh Dissertation Grant to E.M.C., the American Psychological Foundation Elizabeth Munsterberg Koppitz Child Psychology Graduate Fellowship to E.M.C., a Dissertation Funding Award from the Society for Research in Child Development to E.M.C., a Dissertation Research Award from the American Psychological Association to E.M.C., a Scholar Award granted by the International Chapter of the Philanthropic Educational Organization (P.E.O. Foundation) to P.O., and a Ford Foundation Predoctoral Fellowship to C.C. Funding Information: This work was supported by the National Institutes of Health (NIH) Director{\^a}€{\texttrademark}s Early Independence Award (DP5OD021370) to D.G.G., Brain & Behavior Research Foundation (National Alliance for Research on Schizophrenia and Depression; NARSAD) Young Investigator Award to D.G.G., Jacobs Foundation Early Career Research Fellowship to D.G.G., The Society for Clinical Child and Adolescent Psychology (Division 53 of the American Psychological Association) Richard {"}Dick{"} Abidin Early Career Award and Grant to D.G.G., National Science Foundation (NSF) GRFP Awards to E.M.C. (NSF DGE1752134) and P.O. (NSF DGE-1122492), The Society for Clinical Child and Adolescent Psychology (Division 53 of the American Psychological Association) Donald Routh Dissertation Grant to E.M.C., the American Psychological Foundation Elizabeth Munsterberg Koppitz Child Psychology Graduate Fellowship to E.M.C., a Dissertation Funding Award from the Society for Research in Child Development to E.M.C., a Dissertation Research Award from the American Psychological Association to E.M.C., a Scholar Award granted by the International Chapter of the Philanthropic Educational Organization (P.E.O. Foundation) to P.O., and a Ford Foundation Predoctoral Fellowship to C.C. Publisher Copyright: {\textcopyright} The Author(s), 2022. Published by Cambridge University Press.",
year = "2023",
month = feb,
day = "17",
doi = "10.1017/S0954579421001498",
language = "English (US)",
volume = "35",
pages = "218--227",
journal = "Development and Psychopathology",
issn = "0954-5794",
publisher = "Cambridge University Press",
number = "1",
}