Neural stem cells: Progenitors or panacea?

Corinna Klein, Gord Fishell

Research output: Contribution to journalReview articlepeer-review


Are neural stem cells (NSCs) maintained as totipotent precursors by the specialized environment within the stem cell niche or are they simply progenitors, which, while retaining their ability to proliferate, are parcellated and restricted along with their postmitotic brethren? In this review, we focus on what has been learned in recent years about endogenous populations of NSCs in the embryonic and adult brain. We compare the data garnered from in vitro analysis to what has been learned from the transplantation of NSCs into the developing, adult or lesioned brain.

Original languageEnglish (US)
Pages (from-to)82-92
Number of pages11
JournalDevelopmental Neuroscience
Issue number2-4
StatePublished - 2004


  • Cell fate
  • Embryonic stem cells
  • Grafting
  • Neural stem cells
  • Transplantation

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience


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