Neural Substrates of Conditioned Fear and Anxiety

M. H. Monfils; D. E.A. Bush; J. E. LeDoux

doi:10.1016/B978-0-08-045396-5.00093-2

Neural Substrates of Conditioned Fear and Anxiety

M. H. Monfils, D. E.A. Bush, J. E. LeDoux

Neural Science

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Exaggerated or persistent fear is common in psychiatric disorders; this includes anxiety disorders in which altered fear is often a central condition, as well as others in which they are comorbid concomitant. Fear and anxiety engage a complex network of structures; however, when both behavior and underlying circuitry are reduced to a more basic form, a powerful framework emerges from which fear can be studied. This framework can be used to study the neural changes associated with normal fear learning, as well as the mechanisms that underlie many psychiatric disorders that arise from fear dysregulation.

Original language	English (US)
Title of host publication	Encyclopedia of Behavioral Neuroscience, Three-Volume Set, 1-3
Publisher	Elsevier
Pages	V2-362-V2-368
Volume	2
ISBN (Electronic)	9780080453965
ISBN (Print)	9780080914558
DOIs	https://doi.org/10.1016/B978-0-08-045396-5.00093-2
State	Published - Jan 1 2010

Keywords

Amygdala
Anxiety
Behavior
Cellular mechanisms
Emotion
Fear conditioning
Learning
Memory
Plasticity
Potentiation

ASJC Scopus subject areas

General Medicine
General Neuroscience

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10.1016/B978-0-08-045396-5.00093-2

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KW - Learning

KW - Memory

KW - Plasticity

KW - Potentiation

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Neural Substrates of Conditioned Fear and Anxiety

Abstract

Keywords

ASJC Scopus subject areas

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