Neural Substrates of Conditioned Fear and Anxiety

M. H. Monfils, D. E.A. Bush, J. E. LeDoux

Research output: Chapter in Book/Report/Conference proceedingChapter


Exaggerated or persistent fear is common in psychiatric disorders; this includes anxiety disorders in which altered fear is often a central condition, as well as others in which they are comorbid concomitant. Fear and anxiety engage a complex network of structures; however, when both behavior and underlying circuitry are reduced to a more basic form, a powerful framework emerges from which fear can be studied. This framework can be used to study the neural changes associated with normal fear learning, as well as the mechanisms that underlie many psychiatric disorders that arise from fear dysregulation.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Behavioral Neuroscience, Three-Volume Set, 1-3
ISBN (Electronic)9780080453965
ISBN (Print)9780080914558
StatePublished - Jan 1 2010


  • Amygdala
  • Anxiety
  • Behavior
  • Cellular mechanisms
  • Emotion
  • Fear conditioning
  • Learning
  • Memory
  • Plasticity
  • Potentiation

ASJC Scopus subject areas

  • General Medicine
  • General Neuroscience


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