Neuro-evo-devo in the single cell sequencing era

Nikos Konstantinides, Sophie Degabriel, Claude Desplan

Research output: Contribution to journalReview articlepeer-review


The nervous system represents the most complex tissue in animals. How this complexity evolved has been a challenging question to address. The explosion in single cell sequencing techniques, the development of new algorithms to cluster single cells into cell types, along with powerful tools for drawing developmental trajectories offer a unique opportunity to compare homologous cell types between species. They further permit the identification of key developmental points and transcription factors that can lead to the evolution of new cell types. At the same time, the ease of use and efficiency of CRISPR genome editing technology allow validation of predicted regulators. This promises exciting developments in the next few years in the field of neuronal evolution and development.

Original languageEnglish (US)
Pages (from-to)32-40
Number of pages9
JournalCurrent Opinion in Systems Biology
StatePublished - Oct 2018

ASJC Scopus subject areas

  • Modeling and Simulation
  • General Biochemistry, Genetics and Molecular Biology
  • Drug Discovery
  • Computer Science Applications
  • Applied Mathematics


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