NeuroGene: Integrated simulation of Gene regulation, neural activity and neurodevelopment

Rasmus Storjohann; Gary F. Marcus

doi:10.1109/IJCNN.2005.1555869

NeuroGene: Integrated simulation of Gene regulation, neural activity and neurodevelopment

Rasmus Storjohann, Gary F. Marcus

Psychology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

A challenge to understanding the mind and brain is to integrate biochemical, genetic, developmental and neuroscientific information. We present a system for integrated simulation of biochemistry, neurodevelopment and neural activity within a unifying framework of genetic control. Using this system, we have developed a novel model for the formation of topographic projections. We also simulate activity-dependent developmental processes which underlie receptive field refinement and ocular dominance column formation. As an illustration of the overall utility of integrated neurogenetic simulation, we show how axon guidance and learning together may explain the results of a critical study of topographic map development (Brown et al., 2000, Cell).

Original language	English (US)
Title of host publication	Proceedings of the International Joint Conference on Neural Networks, IJCNN 2005
Pages	428-433
Number of pages	6
DOIs	https://doi.org/10.1109/IJCNN.2005.1555869
State	Published - 2005
Event	International Joint Conference on Neural Networks, IJCNN 2005 - Montreal, QC, Canada Duration: Jul 31 2005 → Aug 4 2005

Publication series

Name	Proceedings of the International Joint Conference on Neural Networks
Volume	1

Other

Other	International Joint Conference on Neural Networks, IJCNN 2005
Country/Territory	Canada
City	Montreal, QC
Period	7/31/05 → 8/4/05

ASJC Scopus subject areas

Software
Artificial Intelligence

Access to Document

10.1109/IJCNN.2005.1555869

Cite this

NeuroGene: Integrated simulation of Gene regulation, neural activity and neurodevelopment. / Storjohann, Rasmus; Marcus, Gary F.
Proceedings of the International Joint Conference on Neural Networks, IJCNN 2005. 2005. p. 428-433 1555869 (Proceedings of the International Joint Conference on Neural Networks; Vol. 1).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Storjohann, R & Marcus, GF 2005, NeuroGene: Integrated simulation of Gene regulation, neural activity and neurodevelopment. in Proceedings of the International Joint Conference on Neural Networks, IJCNN 2005., 1555869, Proceedings of the International Joint Conference on Neural Networks, vol. 1, pp. 428-433, International Joint Conference on Neural Networks, IJCNN 2005, Montreal, QC, Canada, 7/31/05. https://doi.org/10.1109/IJCNN.2005.1555869

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NeuroGene: Integrated simulation of Gene regulation, neural activity and neurodevelopment

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