NeuroGene: Integrated simulation of Gene regulation, neural activity and neurodevelopment

Rasmus Storjohann, Gary F. Marcus

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A challenge to understanding the mind and brain is to integrate biochemical, genetic, developmental and neuroscientific information. We present a system for integrated simulation of biochemistry, neurodevelopment and neural activity within a unifying framework of genetic control. Using this system, we have developed a novel model for the formation of topographic projections. We also simulate activity-dependent developmental processes which underlie receptive field refinement and ocular dominance column formation. As an illustration of the overall utility of integrated neurogenetic simulation, we show how axon guidance and learning together may explain the results of a critical study of topographic map development (Brown et al., 2000, Cell).

Original languageEnglish (US)
Title of host publicationProceedings of the International Joint Conference on Neural Networks, IJCNN 2005
Pages428-433
Number of pages6
DOIs
StatePublished - 2005
EventInternational Joint Conference on Neural Networks, IJCNN 2005 - Montreal, QC, Canada
Duration: Jul 31 2005Aug 4 2005

Publication series

NameProceedings of the International Joint Conference on Neural Networks
Volume1

Other

OtherInternational Joint Conference on Neural Networks, IJCNN 2005
CountryCanada
CityMontreal, QC
Period7/31/058/4/05

ASJC Scopus subject areas

  • Software
  • Artificial Intelligence

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    Storjohann, R., & Marcus, G. F. (2005). NeuroGene: Integrated simulation of Gene regulation, neural activity and neurodevelopment. In Proceedings of the International Joint Conference on Neural Networks, IJCNN 2005 (pp. 428-433). [1555869] (Proceedings of the International Joint Conference on Neural Networks; Vol. 1). https://doi.org/10.1109/IJCNN.2005.1555869