Neuronal birthdate underlies the development of striatal compartments

Derek van der Kooy, Gord Fishell

Research output: Contribution to journalArticle

Abstract

The striatum of the mammalian forebrain is composed of two complementary functional compartments, the patches and the matrix. By injecting [3H]thymidine at different embryonic times and sacrificing the rats as young adults, we found that the earliest neurons to leave the mitotic cycle were restricted to the patch compartment. Neurons that became postmitotic at later times preferentially joined the matrix compartment. Distinctive periods of cell proliferation may underline pattern formation throughout the developing forebrain.

Original languageEnglish (US)
Pages (from-to)155-161
Number of pages7
JournalBrain Research
Volume401
Issue number1
DOIs
StatePublished - Jan 13 1987

Keywords

  • Compartment
  • Development
  • Opiate receptor
  • Striatum
  • [H]Thymidine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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