Neuronal birthdate underlies the development of striatal compartments

Derek van der Kooy; Gord Fishell

doi:10.1016/0006-8993(87)91176-0

Neuronal birthdate underlies the development of striatal compartments

Derek van der Kooy, Gord Fishell

Center for Genomics and Systems Biology

Research output: Contribution to journal › Article › peer-review

Abstract

The striatum of the mammalian forebrain is composed of two complementary functional compartments, the patches and the matrix. By injecting [³H]thymidine at different embryonic times and sacrificing the rats as young adults, we found that the earliest neurons to leave the mitotic cycle were restricted to the patch compartment. Neurons that became postmitotic at later times preferentially joined the matrix compartment. Distinctive periods of cell proliferation may underline pattern formation throughout the developing forebrain.

Original language	English (US)
Pages (from-to)	155-161
Number of pages	7
Journal	Brain Research
Volume	401
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(87)91176-0
State	Published - Jan 13 1987

Keywords

Compartment
Development
Opiate receptor
Striatum
[H]Thymidine

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(87)91176-0

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abstract = "The striatum of the mammalian forebrain is composed of two complementary functional compartments, the patches and the matrix. By injecting [3H]thymidine at different embryonic times and sacrificing the rats as young adults, we found that the earliest neurons to leave the mitotic cycle were restricted to the patch compartment. Neurons that became postmitotic at later times preferentially joined the matrix compartment. Distinctive periods of cell proliferation may underline pattern formation throughout the developing forebrain.",

keywords = "Compartment, Development, Opiate receptor, Striatum, [H]Thymidine",

author = "{van der Kooy}, Derek and Gord Fishell",

note = "Funding Information: Thanks to Angelo Izzo for his excellent technical assistance. Supported by the Medical Research Council of Canada.",

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N2 - The striatum of the mammalian forebrain is composed of two complementary functional compartments, the patches and the matrix. By injecting [3H]thymidine at different embryonic times and sacrificing the rats as young adults, we found that the earliest neurons to leave the mitotic cycle were restricted to the patch compartment. Neurons that became postmitotic at later times preferentially joined the matrix compartment. Distinctive periods of cell proliferation may underline pattern formation throughout the developing forebrain.

AB - The striatum of the mammalian forebrain is composed of two complementary functional compartments, the patches and the matrix. By injecting [3H]thymidine at different embryonic times and sacrificing the rats as young adults, we found that the earliest neurons to leave the mitotic cycle were restricted to the patch compartment. Neurons that became postmitotic at later times preferentially joined the matrix compartment. Distinctive periods of cell proliferation may underline pattern formation throughout the developing forebrain.

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KW - Development

KW - Opiate receptor

KW - Striatum

KW - [H]Thymidine

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Neuronal birthdate underlies the development of striatal compartments

Abstract

Keywords

ASJC Scopus subject areas

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