Neuronal expression of NOS-1 is required for host recovery from viral encephalitis

Takashi Komatsu, Derek D C Ireland, Nannan Chen, Carol Shoshkes Reiss

Research output: Contribution to journalArticle

Abstract

The role of nitric oxide synthase (NOS) in host defense and clearance of vesicular stomatitis virus (VSV) from the central nervous system (CNS) was examined. NOS-1, NOS-2, and NOS-3 knockout mice were infected with VSV and were treated with either IL-12 or medium. IL-12 treatment resulted in substantially decreased VSV titers in wildtype and NOS-3 knockout mice, but had a marginal effect in the NOS-1 and NOS-2 knockout mice, NOS-1 expression in neurons was associated with survival from VSV infection. The data indicate that the enzyme activity is local, since NOS-2 expression in microglia and inflammatory macrophages and NOS-3 expression in astrocytes, endothelial cells, and ependymal cells did not compensate.

Original languageEnglish (US)
Pages (from-to)389-395
Number of pages7
JournalVirology
Volume258
Issue number2
DOIs
StatePublished - Jun 5 1999

Keywords

  • Acquired immunity
  • Innate immunity
  • Interleukin-12
  • Nitric oxide synthase
  • Viral infection

ASJC Scopus subject areas

  • Virology

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