Neuronal Inactivity Co-opts LTP Machinery to Drive Potassium Channel Splicing and Homeostatic Spike Widening

Boxing Li, Benjamin S. Suutari, Simón(e) D. Sun, Zhengyi Luo, Chuanchuan Wei, Nicolas Chenouard, Nataniel J. Mandelberg, Guoan Zhang, Brie Wamsley, Guoling Tian, Sandrine Sanchez, Sikun You, Lianyan Huang, Thomas A. Neubert, Gordon Fishell, Richard W. Tsien

Research output: Contribution to journalArticlepeer-review

Abstract

Silencing neuronal activity triggers similar molecular mechanisms as activating neurons during long-term potentiation, demonstrating Hebbian mechanisms of homeostatic spike regulation.

Original languageEnglish (US)
Pages (from-to)1547-1565.e15
JournalCell
Volume181
Issue number7
DOIs
StatePublished - Jun 25 2020

Keywords

  • Alternative splicing
  • BK channel
  • CaM kinase
  • Nova-2
  • action potential duration
  • chronic inactivity
  • homeostasis
  • synaptic activity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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