Neuronal thresholds and choice-related activity of otolith afferent fibers during heading perception

Xiong Jie Yu, J. David Dickman, Gregory C. DeAngelis, Dora E. Angelaki

Research output: Contribution to journalArticlepeer-review

Abstract

How activity of sensory neurons leads to perceptual decisions remains a challenge to understand. Correlations between choices and single neuron firing rates have been found early in vestibular processing, in the brainstem and cerebellum. To investigate the origins of choice-related activity, we have recorded from otolith afferent fibers while animals performed a fine heading discrimination task. We find that afferent fibers have similar discrimination thresholds as central cells, and the most sensitive fibers have thresholds that are only twofold or threefold greater than perceptual thresholds. Unlike brainstem and cerebellar nuclei neurons, spike counts from afferent fibers do not exhibit trial-by-trial correlations with perceptual decisions. This finding may reflect the fact that otolith afferent responses are poorly suited for driving heading perception because they fail to discriminate self-motion from changes in orientation relative to gravity. Alternatively, if choice probabilities reflect top-down inference signals, they are not relayed to the vestibular periphery.

Original languageEnglish (US)
Pages (from-to)6467-6472
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume112
Issue number20
DOIs
StatePublished - May 19 2015

Keywords

  • Choice probability
  • Heading discrimination
  • Neuronal threshold
  • Otolith afferent
  • Psychophysical threshold

ASJC Scopus subject areas

  • General

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