Neuropeptides and leukotriene biosynthesis: The effect of calcitonin, peptide histidine valine-42, helodermin, neuropeptide Y and galanin

Vincenzo Di Marzo, John R. Tippins, Sehamuddin H.I. Galadari, Howard R. Morris

Research output: Contribution to journalArticle

Abstract

The effect of five neuropeptides was tested on platelet activating factor (PAF)-stimulated peptidoleukotriene biosynthesis in rat lungs. Calcitonin and peptide histidine valine-42 (PHV-42) were found to inhibit leukotriene C4 (LTC4) and D4 (LTD4) biosynthesis to an extent similar to the previously reported effects of calcitonin gene-related peptide (CGRP) and peptide histidine isoleucine (PHI) respectively. Helodermin potently inhibited the biosynthesis of all three peptidoleukotrienes. Neuropeptide Y and galanin, both present in airways, enhanced the levels of LTD4 and had no effect on LTC4 or leukotriene E4 (LTE4) levels. The theoretical implications of these findings are discussed.

Original languageEnglish (US)
Pages (from-to)169-172
Number of pages4
JournalNeuropeptides
Volume11
Issue number4
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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