Neurosyphilis in patients with human immunodeficiency virus infection

Edmund C. Tramont; J. Rodriguez-Baño; G. Izquierdo; M. A. Muniain; Marc N. Gourevitch; Robert S. Klein; Ellie E. Schoenbaum; Steven M. Gordon; Molly E. Eaton; Sheila A. Lukehart; Harold Horowitz; Gary P. Wormser; Konrad Wicher

doi:10.1056/NEJM199504273321712

Neurosyphilis in patients with human immunodeficiency virus infection

Edmund C. Tramont, J. Rodriguez-Baño, G. Izquierdo, M. A. Muniain, Marc N. Gourevitch, Robert S. Klein, Ellie E. Schoenbaum, Steven M. Gordon, Molly E. Eaton, Sheila A. Lukehart, Harold Horowitz, Gary P. Wormser, Konrad Wicher

Urban Initiative

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Abstract

To the Editor: The reports by Gordon et al. and Horowitz et al. (Dec. 1 issue)¹,² appropriately question the effectiveness of high-dose penicillin as a treatment for syphilis in persons infected with the human immunodeficiency virus (HIV). However, these reports do not prove that such treatment is ineffective. The polymerase-chain-reaction (PCR) tests used do not necessarily indicate the presence of replicating organisms. In addition, an immunologic marker, especially a nonspecific one such as the Venereal Disease Research Laboratory (VDRL) or rapid plasma reagin titer, cannot be relied on to indicate successful treatment in persons who are immunologically dysfunctional. Patients.

Original language	English (US)
Pages (from-to)	1169-1171
Number of pages	3
Journal	New England Journal of Medicine
Volume	332
Issue number	17
DOIs	https://doi.org/10.1056/NEJM199504273321712
State	Published - Apr 27 1995

ASJC Scopus subject areas

General Medicine

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Tramont, E. C., Rodriguez-Baño, J., Izquierdo, G., Muniain, M. A., Gourevitch, M. N., Klein, R. S., Schoenbaum, E. E., Gordon, S. M., Eaton, M. E., Lukehart, S. A., Horowitz, H., Wormser, G. P., & Wicher, K. (1995). Neurosyphilis in patients with human immunodeficiency virus infection. New England Journal of Medicine, 332(17), 1169-1171. https://doi.org/10.1056/NEJM199504273321712

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title = "Neurosyphilis in patients with human immunodeficiency virus infection",

abstract = "To the Editor: The reports by Gordon et al. and Horowitz et al. (Dec. 1 issue)1,2 appropriately question the effectiveness of high-dose penicillin as a treatment for syphilis in persons infected with the human immunodeficiency virus (HIV). However, these reports do not prove that such treatment is ineffective. The polymerase-chain-reaction (PCR) tests used do not necessarily indicate the presence of replicating organisms. In addition, an immunologic marker, especially a nonspecific one such as the Venereal Disease Research Laboratory (VDRL) or rapid plasma reagin titer, cannot be relied on to indicate successful treatment in persons who are immunologically dysfunctional. Patients.",

author = "Tramont, {Edmund C.} and J. Rodriguez-Ba{\~n}o and G. Izquierdo and Muniain, {M. A.} and Gourevitch, {Marc N.} and Klein, {Robert S.} and Schoenbaum, {Ellie E.} and Gordon, {Steven M.} and Eaton, {Molly E.} and Lukehart, {Sheila A.} and Harold Horowitz and Wormser, {Gary P.} and Konrad Wicher",

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doi = "10.1056/NEJM199504273321712",

language = "English (US)",

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T1 - Neurosyphilis in patients with human immunodeficiency virus infection

AU - Tramont, Edmund C.

AU - Rodriguez-Baño, J.

AU - Izquierdo, G.

AU - Muniain, M. A.

AU - Gourevitch, Marc N.

AU - Klein, Robert S.

AU - Schoenbaum, Ellie E.

AU - Gordon, Steven M.

AU - Eaton, Molly E.

AU - Lukehart, Sheila A.

AU - Horowitz, Harold

AU - Wormser, Gary P.

AU - Wicher, Konrad

PY - 1995/4/27

Y1 - 1995/4/27

N2 - To the Editor: The reports by Gordon et al. and Horowitz et al. (Dec. 1 issue)1,2 appropriately question the effectiveness of high-dose penicillin as a treatment for syphilis in persons infected with the human immunodeficiency virus (HIV). However, these reports do not prove that such treatment is ineffective. The polymerase-chain-reaction (PCR) tests used do not necessarily indicate the presence of replicating organisms. In addition, an immunologic marker, especially a nonspecific one such as the Venereal Disease Research Laboratory (VDRL) or rapid plasma reagin titer, cannot be relied on to indicate successful treatment in persons who are immunologically dysfunctional. Patients.

AB - To the Editor: The reports by Gordon et al. and Horowitz et al. (Dec. 1 issue)1,2 appropriately question the effectiveness of high-dose penicillin as a treatment for syphilis in persons infected with the human immunodeficiency virus (HIV). However, these reports do not prove that such treatment is ineffective. The polymerase-chain-reaction (PCR) tests used do not necessarily indicate the presence of replicating organisms. In addition, an immunologic marker, especially a nonspecific one such as the Venereal Disease Research Laboratory (VDRL) or rapid plasma reagin titer, cannot be relied on to indicate successful treatment in persons who are immunologically dysfunctional. Patients.

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JF - New England Journal of Medicine

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Neurosyphilis in patients with human immunodeficiency virus infection

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