Neurosyphilis in patients with human immunodeficiency virus infection

Edmund C. Tramont, J. Rodriguez-Baño, G. Izquierdo, M. A. Muniain, Marc N. Gourevitch, Robert S. Klein, Ellie E. Schoenbaum, Steven M. Gordon, Molly E. Eaton, Sheila A. Lukehart, Harold Horowitz, Gary P. Wormser, Konrad Wicher

Research output: Contribution to journalLetterpeer-review


To the Editor: The reports by Gordon et al. and Horowitz et al. (Dec. 1 issue)1,2 appropriately question the effectiveness of high-dose penicillin as a treatment for syphilis in persons infected with the human immunodeficiency virus (HIV). However, these reports do not prove that such treatment is ineffective. The polymerase-chain-reaction (PCR) tests used do not necessarily indicate the presence of replicating organisms. In addition, an immunologic marker, especially a nonspecific one such as the Venereal Disease Research Laboratory (VDRL) or rapid plasma reagin titer, cannot be relied on to indicate successful treatment in persons who are immunologically dysfunctional. Patients.

Original languageEnglish (US)
Pages (from-to)1169-1171
Number of pages3
JournalNew England Journal of Medicine
Issue number17
StatePublished - Apr 27 1995

ASJC Scopus subject areas

  • General Medicine


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