Neurotensin: A new 'reward peptide'

Paul W. Glimcher; David H. Margolin; Adrienne A. Giovino; Bartley G. Hoebel

doi:10.1016/0006-8993(84)90657-7

Neurotensin: A new 'reward peptide'

Paul W. Glimcher, David H. Margolin, Adrienne A. Giovino, Bartley G. Hoebel

Neural Science

Research output: Contribution to journal › Article › peer-review

Abstract

Neurotensin (NT) is a tridecapeptide which is thought to bind to receptors located on dopamine cells in the ventral tegmental area (VTA). Rats with cannulas implanted in the VTA showed a significant increase in time spent in an environment in which they had received bilateral injections of neurotensin on previous days. This is indicative of conditioned reinforcement in which the neuropeptide was the primary reinforcer. In order to determine the specificity of neurotensin receptor interactions, 3 fragments of the peptide were examined at 2 doses. NT_1-8 and NT_8-13 were found to be inactive while NT_1-11 demonstrated significant activity. The results suggest that NT in the VTA is capable of inducing reinforcing effects. This is the first evidence for a non-opiate 'reward peptide'.

Original language	English (US)
Pages (from-to)	119-124
Number of pages	6
Journal	Brain Research
Volume	291
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(84)90657-7
State	Published - Jan 16 1984

Keywords

behavior
brain
midbrain
neurotensin
neurotensin fragments
place preference test
reward

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(84)90657-7

Cite this

@article{faa7e7cdd6bd4f5394c034b2e93ef08e,

title = "Neurotensin: A new 'reward peptide'",

abstract = "Neurotensin (NT) is a tridecapeptide which is thought to bind to receptors located on dopamine cells in the ventral tegmental area (VTA). Rats with cannulas implanted in the VTA showed a significant increase in time spent in an environment in which they had received bilateral injections of neurotensin on previous days. This is indicative of conditioned reinforcement in which the neuropeptide was the primary reinforcer. In order to determine the specificity of neurotensin receptor interactions, 3 fragments of the peptide were examined at 2 doses. NT1-8 and NT8-13 were found to be inactive while NT1-11 demonstrated significant activity. The results suggest that NT in the VTA is capable of inducing reinforcing effects. This is the first evidence for a non-opiate 'reward peptide'.",

keywords = "behavior, brain, midbrain, neurotensin, neurotensin fragments, place preference test, reward",

author = "Glimcher, {Paul W.} and Margolin, {David H.} and Giovino, {Adrienne A.} and Hoebel, {Bartley G.}",

note = "Funding Information: The authors express their appreciation to Kathy McGeady for her assistance. This work was supported by PHS Grant MH-35740.",

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doi = "10.1016/0006-8993(84)90657-7",

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T2 - A new 'reward peptide'

AU - Glimcher, Paul W.

AU - Margolin, David H.

AU - Giovino, Adrienne A.

AU - Hoebel, Bartley G.

N1 - Funding Information: The authors express their appreciation to Kathy McGeady for her assistance. This work was supported by PHS Grant MH-35740.

PY - 1984/1/16

Y1 - 1984/1/16

N2 - Neurotensin (NT) is a tridecapeptide which is thought to bind to receptors located on dopamine cells in the ventral tegmental area (VTA). Rats with cannulas implanted in the VTA showed a significant increase in time spent in an environment in which they had received bilateral injections of neurotensin on previous days. This is indicative of conditioned reinforcement in which the neuropeptide was the primary reinforcer. In order to determine the specificity of neurotensin receptor interactions, 3 fragments of the peptide were examined at 2 doses. NT1-8 and NT8-13 were found to be inactive while NT1-11 demonstrated significant activity. The results suggest that NT in the VTA is capable of inducing reinforcing effects. This is the first evidence for a non-opiate 'reward peptide'.

AB - Neurotensin (NT) is a tridecapeptide which is thought to bind to receptors located on dopamine cells in the ventral tegmental area (VTA). Rats with cannulas implanted in the VTA showed a significant increase in time spent in an environment in which they had received bilateral injections of neurotensin on previous days. This is indicative of conditioned reinforcement in which the neuropeptide was the primary reinforcer. In order to determine the specificity of neurotensin receptor interactions, 3 fragments of the peptide were examined at 2 doses. NT1-8 and NT8-13 were found to be inactive while NT1-11 demonstrated significant activity. The results suggest that NT in the VTA is capable of inducing reinforcing effects. This is the first evidence for a non-opiate 'reward peptide'.

KW - behavior

KW - brain

KW - midbrain

KW - neurotensin

KW - neurotensin fragments

KW - place preference test

KW - reward

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JO - Brain Research

JF - Brain Research

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ER -

Neurotensin: A new 'reward peptide'

Abstract

Keywords

ASJC Scopus subject areas

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