Neurotensin self-injection in the ventral tegmental area

Paul W. Glimcher; Adrienne A. Giovino; Bartley G. Hoebel

doi:10.1016/0006-8993(87)90134-X

Neurotensin self-injection in the ventral tegmental area

Paul W. Glimcher, Adrienne A. Giovino, Bartley G. Hoebel

Neural Science

Research output: Contribution to journal › Article › peer-review

Abstract

Earlier work with the conditioned place-preference paradigm suggested that neurotensin (NT) acts as a behavioral reinforcer when microinjected into the ventral tegmental area (VTA) of the midbrain. We report here that animals will perform an operant task to obtain microinfusions of NT into the VTA. Rats reliably pressed a lever to obtain NT infusions while neglecting an identical but inactive lever. Substitution of saline for NT initiated response extinction; following the reintroduction of NT, reliable responding resumed. These results extend earlier work suggesting that NT in the VTA can be a positive reinforcer.

Original language	English (US)
Pages (from-to)	147-150
Number of pages	4
Journal	Brain Research
Volume	403
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(87)90134-X
State	Published - Feb 10 1987

Keywords

Neurotensin
Reward
Self-injection
Ventral tegmental area

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(87)90134-X

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abstract = "Earlier work with the conditioned place-preference paradigm suggested that neurotensin (NT) acts as a behavioral reinforcer when microinjected into the ventral tegmental area (VTA) of the midbrain. We report here that animals will perform an operant task to obtain microinfusions of NT into the VTA. Rats reliably pressed a lever to obtain NT infusions while neglecting an identical but inactive lever. Substitution of saline for NT initiated response extinction; following the reintroduction of NT, reliable responding resumed. These results extend earlier work suggesting that NT in the VTA can be a positive reinforcer.",

keywords = "Neurotensin, Reward, Self-injection, Ventral tegmental area",

author = "Glimcher, {Paul W.} and Giovino, {Adrienne A.} and Hoebel, {Bartley G.}",

note = "Funding Information: A portion of this work was presented at the Meeting of the Society for Neurosciences, 1983, abstract 35.6. The research was supported by PHS Grant MH-35740.",

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AU - Glimcher, Paul W.

AU - Giovino, Adrienne A.

AU - Hoebel, Bartley G.

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AB - Earlier work with the conditioned place-preference paradigm suggested that neurotensin (NT) acts as a behavioral reinforcer when microinjected into the ventral tegmental area (VTA) of the midbrain. We report here that animals will perform an operant task to obtain microinfusions of NT into the VTA. Rats reliably pressed a lever to obtain NT infusions while neglecting an identical but inactive lever. Substitution of saline for NT initiated response extinction; following the reintroduction of NT, reliable responding resumed. These results extend earlier work suggesting that NT in the VTA can be a positive reinforcer.

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KW - Self-injection

KW - Ventral tegmental area

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Neurotensin self-injection in the ventral tegmental area

Abstract

Keywords

ASJC Scopus subject areas

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