@article{f2dc85358995499094040885f1d82265,
title = "Neutrophil-mediated endogenous analgesia contributes to sex differences in oral cancer pain",
abstract = "The incidence of oral cancer in the United States is increasing, especially in young people and women. Patients with oral cancer report severe functional pain. Using a patient cohort accrued through the New York University Oral Cancer Center and immune-competent mouse models, we identify a sex difference in the prevalence and severity of oral cancer pain. A neutrophil-mediated endogenous analgesic mechanism is present in male mice with oral cancer. Local naloxone treatment potentiates cancer mediator-induced orofacial nociceptive behavior in male mice only. Tongues from male mice with oral cancer have significantly more infiltrating neutrophils compared to female mice with oral cancer. Neutrophils isolated from the cancer-induced inflammatory microenvironment express beta-endorphin and met-enkephalin. Furthermore, neutrophil depletion results in nociceptive behavior in male mice. These data suggest a role for sex-specific, immune cell-mediated endogenous analgesia in the treatment of oral cancer pain.",
keywords = "Cancer, Endogenous analgesia, Neutrophils, Opioids, Orofacial, Pain, Sex differences, Squamous cell carcinoma",
author = "Scheff, {Nicole N.} and Aditi Bhattacharya and Edward Dowse and Dang, {Richard X.} and Dolan, {John C.} and Susanna Wang and Hyesung Kim and Albertson, {Donna G.} and Schmidt, {Brian L.}",
note = "Funding Information: We thank Mr. Yogin Patel as well as Dr. David Levy and the New York University College of Dentistry Flow Cytometry Facility for their technical contributions. We acknowledge the cell sorting technologies provided by NYU Langone{\textquoteright}s Cytometry and Cell Sorting Laboratory that is supported in part by NIH/NCI P30CA016087. Funding Information: This work was supported by the National Institute of Dental and Craniofacial Research through individual investigator grant F32 DE027269 (NS) and grant R01 DE025393 (BS). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Funding Information: We thank Mr. Yogin Patel as well as Dr. David Levy and the New York University College of Dentistry Flow Cytometry Facility for their technical contributions. We acknowledge the cell sorting technologies provided by NYU Langone{\textquoteright}s Cytometry and Cell Sorting Laboratory that is supported in part by NIH/NCI P30CA016087. Funding. This work was supported by the National Institute of Dental and Craniofacial Research through individual investigator grant F32 DE027269 (NS) and grant R01 DE025393 (BS). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2018 Scheff, Bhattacharya, Dowse, Dang, Dolan, Wang, Kim, Albertson and Schmidt.",
year = "2018",
month = oct,
day = "22",
doi = "10.3389/fnint.2018.00052",
language = "English (US)",
volume = "12",
journal = "Frontiers in Integrative Neuroscience",
issn = "1662-5145",
publisher = "Frontiers Research Foundation",
}